Progesterone exacerbates short-term effects of traumatic brain injury on supragranular responses in sensory cortex and over-excites infragranular responses in the long term.

Victoria Prowse, B. Allitt, K.L. L. Richards, E Yan, R. Rajan

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Gas hydrate formation is a critical flow assurance risk in oil and gas production, as remediation of blockages may require weeks of operating downtime and represent a significant safety hazard. While many studies over the past two decades have focused on quantifying hydrate blockage risk in crude oil systems, there is a dearth of information available with which to assess hydrate growth rate or blockage severity in natural gas systems, which typically operate between stratified and annular flow regimes. In this investigation, a single-pass gas-dominant flowloop was used to measure hydrate growth and particle deposition rates with variable liquid holdup (1–10 vol%) and subcooling (1–20 °C). A particular focus of this study was the impact of reducing the gas phase velocity to achieve lower liquid entrainment and, therefore, decrease hydrate formation rate. Reducing the gas velocity from 8.7 to 4.6 m/s at a constant subcooling around 6 °C reduced the total formation rate by a factor of six. At these conditions, the sensitivity of hydrate formation rate to velocity was about 40 times greater than the sensitivity to subcooling. This reduction in gas velocity also halved the estimated rate of hydrate deposition on the pipeline wall. Finally, new observations of hydrate wash-out are reported, whereby significant localized hydrate deposits were effectively removed by modulating the subcooling of the flowloop wall from 6 °C to 3.5 °C. The results provide new insight to inform the next generation of predictive hydrate growth and deposition models for gas-dominant flowlines.
    Original languageEnglish
    Pages (from-to)375-389
    JournalJournal of Neurotrauma
    Volume33
    Issue number4
    DOIs
    Publication statusPublished - 2016

    Fingerprint

    Progesterone
    Gases
    Growth
    Natural Gas
    Petroleum
    Traumatic Brain Injury
    Oils
    Safety

    Cite this

    @article{e28fe90249cf49a3a762f6e169b71a09,
    title = "Progesterone exacerbates short-term effects of traumatic brain injury on supragranular responses in sensory cortex and over-excites infragranular responses in the long term.",
    abstract = "Gas hydrate formation is a critical flow assurance risk in oil and gas production, as remediation of blockages may require weeks of operating downtime and represent a significant safety hazard. While many studies over the past two decades have focused on quantifying hydrate blockage risk in crude oil systems, there is a dearth of information available with which to assess hydrate growth rate or blockage severity in natural gas systems, which typically operate between stratified and annular flow regimes. In this investigation, a single-pass gas-dominant flowloop was used to measure hydrate growth and particle deposition rates with variable liquid holdup (1–10 vol{\%}) and subcooling (1–20 °C). A particular focus of this study was the impact of reducing the gas phase velocity to achieve lower liquid entrainment and, therefore, decrease hydrate formation rate. Reducing the gas velocity from 8.7 to 4.6 m/s at a constant subcooling around 6 °C reduced the total formation rate by a factor of six. At these conditions, the sensitivity of hydrate formation rate to velocity was about 40 times greater than the sensitivity to subcooling. This reduction in gas velocity also halved the estimated rate of hydrate deposition on the pipeline wall. Finally, new observations of hydrate wash-out are reported, whereby significant localized hydrate deposits were effectively removed by modulating the subcooling of the flowloop wall from 6 °C to 3.5 °C. The results provide new insight to inform the next generation of predictive hydrate growth and deposition models for gas-dominant flowlines.",
    author = "Victoria Prowse and B. Allitt and Richards, {K.L. L.} and E Yan and R. Rajan",
    year = "2016",
    doi = "10.1089/neu.2015.3946",
    language = "English",
    volume = "33",
    pages = "375--389",
    journal = "Journal of Neurotrauma",
    issn = "0897-7151",
    publisher = "Mary Ann Liebert Inc",
    number = "4",

    }

    Progesterone exacerbates short-term effects of traumatic brain injury on supragranular responses in sensory cortex and over-excites infragranular responses in the long term. / Prowse, Victoria; Allitt, B.; Richards, K.L. L.; Yan, E; Rajan, R.

    In: Journal of Neurotrauma, Vol. 33, No. 4, 2016, p. 375-389.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Progesterone exacerbates short-term effects of traumatic brain injury on supragranular responses in sensory cortex and over-excites infragranular responses in the long term.

    AU - Prowse, Victoria

    AU - Allitt, B.

    AU - Richards, K.L. L.

    AU - Yan, E

    AU - Rajan, R.

    PY - 2016

    Y1 - 2016

    N2 - Gas hydrate formation is a critical flow assurance risk in oil and gas production, as remediation of blockages may require weeks of operating downtime and represent a significant safety hazard. While many studies over the past two decades have focused on quantifying hydrate blockage risk in crude oil systems, there is a dearth of information available with which to assess hydrate growth rate or blockage severity in natural gas systems, which typically operate between stratified and annular flow regimes. In this investigation, a single-pass gas-dominant flowloop was used to measure hydrate growth and particle deposition rates with variable liquid holdup (1–10 vol%) and subcooling (1–20 °C). A particular focus of this study was the impact of reducing the gas phase velocity to achieve lower liquid entrainment and, therefore, decrease hydrate formation rate. Reducing the gas velocity from 8.7 to 4.6 m/s at a constant subcooling around 6 °C reduced the total formation rate by a factor of six. At these conditions, the sensitivity of hydrate formation rate to velocity was about 40 times greater than the sensitivity to subcooling. This reduction in gas velocity also halved the estimated rate of hydrate deposition on the pipeline wall. Finally, new observations of hydrate wash-out are reported, whereby significant localized hydrate deposits were effectively removed by modulating the subcooling of the flowloop wall from 6 °C to 3.5 °C. The results provide new insight to inform the next generation of predictive hydrate growth and deposition models for gas-dominant flowlines.

    AB - Gas hydrate formation is a critical flow assurance risk in oil and gas production, as remediation of blockages may require weeks of operating downtime and represent a significant safety hazard. While many studies over the past two decades have focused on quantifying hydrate blockage risk in crude oil systems, there is a dearth of information available with which to assess hydrate growth rate or blockage severity in natural gas systems, which typically operate between stratified and annular flow regimes. In this investigation, a single-pass gas-dominant flowloop was used to measure hydrate growth and particle deposition rates with variable liquid holdup (1–10 vol%) and subcooling (1–20 °C). A particular focus of this study was the impact of reducing the gas phase velocity to achieve lower liquid entrainment and, therefore, decrease hydrate formation rate. Reducing the gas velocity from 8.7 to 4.6 m/s at a constant subcooling around 6 °C reduced the total formation rate by a factor of six. At these conditions, the sensitivity of hydrate formation rate to velocity was about 40 times greater than the sensitivity to subcooling. This reduction in gas velocity also halved the estimated rate of hydrate deposition on the pipeline wall. Finally, new observations of hydrate wash-out are reported, whereby significant localized hydrate deposits were effectively removed by modulating the subcooling of the flowloop wall from 6 °C to 3.5 °C. The results provide new insight to inform the next generation of predictive hydrate growth and deposition models for gas-dominant flowlines.

    UR - http://www.scopus.com/inward/record.url?scp=84958999588&partnerID=8YFLogxK

    U2 - 10.1089/neu.2015.3946

    DO - 10.1089/neu.2015.3946

    M3 - Article

    VL - 33

    SP - 375

    EP - 389

    JO - Journal of Neurotrauma

    JF - Journal of Neurotrauma

    SN - 0897-7151

    IS - 4

    ER -