Profound thrombocytopenia related to G-CSF

Jason C. Kovacic; Peter Macdonald; Judith Freund; John E.J. Rasko; Roger Allan; Vivian B. Fernandes; David Ma; John Moore; Robert M. Graham

doi:10.1002/ajh.20787

Profound thrombocytopenia related to G-CSF

Jason C. Kovacic, Peter Macdonald, Judith Freund, John E.J. Rasko, Roger Allan, Vivian B. Fernandes, David Ma, John Moore, Robert M. Graham

Research output: Contribution to journal › Review article › peer-review

22 Citations (Scopus)

Abstract

Severe thrombocytopenia in association with G-CSF therapy is extremely rare. Here we report a case of profound thrombocytopenia in a 57-year-old male with refractory cardiac ischemia, who received G-CSF during an angiogenesis trial. After 5 days of G-CSF therapy (10 μg/kg/day) the platelet count fell progressively to a nadir of 5 × 10⁹/L. The patient received steroid, immunoglobulin and platelet support and recovered without sequelae. Subsequent investigations suggested an underlying immune-mediated thrombocytopenia, which we hypothesize was exacerbated by G-CSF therapy.

Original language	English
Pages (from-to)	229-230
Number of pages	2
Journal	American Journal of Hematology
Volume	82
Issue number	3
DOIs	https://doi.org/10.1002/ajh.20787
Publication status	Published - Mar 2007
Externally published	Yes

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10.1002/ajh.20787

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title = "Profound thrombocytopenia related to G-CSF",

abstract = "Severe thrombocytopenia in association with G-CSF therapy is extremely rare. Here we report a case of profound thrombocytopenia in a 57-year-old male with refractory cardiac ischemia, who received G-CSF during an angiogenesis trial. After 5 days of G-CSF therapy (10 μg/kg/day) the platelet count fell progressively to a nadir of 5 × 109/L. The patient received steroid, immunoglobulin and platelet support and recovered without sequelae. Subsequent investigations suggested an underlying immune-mediated thrombocytopenia, which we hypothesize was exacerbated by G-CSF therapy.",

keywords = "G-CSF, Thrombocytopenia",

author = "Kovacic, \{Jason C.\} and Peter Macdonald and Judith Freund and Rasko, \{John E.J.\} and Roger Allan and Fernandes, \{Vivian B.\} and David Ma and John Moore and Graham, \{Robert M.\}",

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AU - Kovacic, Jason C.

AU - Macdonald, Peter

AU - Freund, Judith

AU - Rasko, John E.J.

AU - Allan, Roger

AU - Fernandes, Vivian B.

AU - Ma, David

AU - Moore, John

AU - Graham, Robert M.

PY - 2007/3

Y1 - 2007/3

N2 - Severe thrombocytopenia in association with G-CSF therapy is extremely rare. Here we report a case of profound thrombocytopenia in a 57-year-old male with refractory cardiac ischemia, who received G-CSF during an angiogenesis trial. After 5 days of G-CSF therapy (10 μg/kg/day) the platelet count fell progressively to a nadir of 5 × 109/L. The patient received steroid, immunoglobulin and platelet support and recovered without sequelae. Subsequent investigations suggested an underlying immune-mediated thrombocytopenia, which we hypothesize was exacerbated by G-CSF therapy.

AB - Severe thrombocytopenia in association with G-CSF therapy is extremely rare. Here we report a case of profound thrombocytopenia in a 57-year-old male with refractory cardiac ischemia, who received G-CSF during an angiogenesis trial. After 5 days of G-CSF therapy (10 μg/kg/day) the platelet count fell progressively to a nadir of 5 × 109/L. The patient received steroid, immunoglobulin and platelet support and recovered without sequelae. Subsequent investigations suggested an underlying immune-mediated thrombocytopenia, which we hypothesize was exacerbated by G-CSF therapy.

KW - G-CSF

KW - Thrombocytopenia

UR - https://www.scopus.com/pages/publications/33847631288

U2 - 10.1002/ajh.20787

DO - 10.1002/ajh.20787

M3 - Review article

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SP - 229

EP - 230

JO - American Journal of Hematology

JF - American Journal of Hematology

IS - 3

ER -

Profound thrombocytopenia related to G-CSF

Abstract

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