Profound thrombocytopenia related to G-CSF

Jason C. Kovacic, Peter Macdonald, Judith Freund, John E.J. Rasko, Roger Allan, Vivian B. Fernandes, David Ma, John Moore, Robert M. Graham

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

Severe thrombocytopenia in association with G-CSF therapy is extremely rare. Here we report a case of profound thrombocytopenia in a 57-year-old male with refractory cardiac ischemia, who received G-CSF during an angiogenesis trial. After 5 days of G-CSF therapy (10 μg/kg/day) the platelet count fell progressively to a nadir of 5 × 109/L. The patient received steroid, immunoglobulin and platelet support and recovered without sequelae. Subsequent investigations suggested an underlying immune-mediated thrombocytopenia, which we hypothesize was exacerbated by G-CSF therapy.

Original languageEnglish
Pages (from-to)229-230
Number of pages2
JournalAmerican Journal of Hematology
Volume82
Issue number3
DOIs
Publication statusPublished - Mar 2007
Externally publishedYes

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