Projects per year
Abstract
Immunoglobulin G (IgG) glycosylation is essential for function of the immune system, but the genetic and environmental factors that underlie its inter-individual variability are not well defined. The Collaborative Cross (CC) genetic resource harnesses over 90% of the common genetic variation of the mouse. By analyzing the IgG glycome composition of 95 CC strains, we made several important observations: (i) glycome variation between mouse strains was higher than between individual humans, despite all mice having the same environmental influences; (ii) five genetic loci were found to be associated with murine IgG glycosylation; (iii) variants outside traditional glycosylation site motifs affected glycome variation; (iv) bisecting N-acetylglucosamine (GlcNAc) was produced by several strains although most previous studies have reported the absence of glycans containing the bisecting GlcNAc on murine IgGs; and (v) common laboratory mouse strains are not optimal animal models for studying effects of glycosylation on IgG function.
Original language | English |
---|---|
Pages (from-to) | 516-524 |
Number of pages | 9 |
Journal | Nature Chemical Biology |
Volume | 14 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 May 2018 |
Fingerprint
Dive into the research topics of 'Profiling and genetic control of the murine immunoglobulin G glycome'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Discovery of genes that protect against Tau-induced neuropathologies
Morahan, G. & Van Eersel, J.
National Health & Medical Research Council NHMRC
1/01/14 → 31/12/16
Project: Research