Production, quality control and initial imaging studies of [ 82mRb]RbCl for PET studies

Pejman Rowshanfarzad; Amir Reza Jalilian; Mohsen Kiyomarsi; Mahsheed Sabet; Ali Reza Karimian; Sedigheh Moradkhani; Mohammad Mirzaii

Production, quality control and initial imaging studies of [ 82mRb]RbCl for PET studies

Pejman Rowshanfarzad, Amir Reza Jalilian, Mohsen Kiyomarsi, Mahsheed Sabet, Ali Reza Karimian, Sedigheh Moradkhani, Mohammad Mirzaii

School of Physics, Mathematics and Computing

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Rubidium-82m was prepared via 15.4 MeV proton irradiation of a krypton-82 gaseous target (30% enrichment). Washing the target chamber with hot water yielded a Rb-82m containing solution, which was further purified using short column chromatography in order to remove organic/inorganic impurities. The flowthrough was formulated in normal saline for injection. Radionuclide, radiochemical and chemical purity tests were performed prior to administration to rats for imaging (radiochemical yield: 95-97%, radiochemical purity > 97%). Preliminary dual-head coincidence studies were performed to determine the distribution of [^82mRb]Rb in normal rats. For biodistribution studies, Rb-81 was injected to rats and tracer accumulation in heart, GI and bladder was determined after sacrification in time intervals. A yield of 1.3 GBq at EOB, 235.7 MBq/μAh was obtained.

Original language	English
Pages (from-to)	209-215
Number of pages	7
Journal	Nukleonika
Volume	51
Issue number	4
Publication status	Published - 30 Nov 2006

Cite this

@article{44c32c9b5a3241eab32cc35df647632a,

title = "Production, quality control and initial imaging studies of [ 82mRb]RbCl for PET studies",

abstract = "Rubidium-82m was prepared via 15.4 MeV proton irradiation of a krypton-82 gaseous target (30% enrichment). Washing the target chamber with hot water yielded a Rb-82m containing solution, which was further purified using short column chromatography in order to remove organic/inorganic impurities. The flowthrough was formulated in normal saline for injection. Radionuclide, radiochemical and chemical purity tests were performed prior to administration to rats for imaging (radiochemical yield: 95-97%, radiochemical purity > 97%). Preliminary dual-head coincidence studies were performed to determine the distribution of [82mRb]Rb in normal rats. For biodistribution studies, Rb-81 was injected to rats and tracer accumulation in heart, GI and bladder was determined after sacrification in time intervals. A yield of 1.3 GBq at EOB, 235.7 MBq/μAh was obtained.",

keywords = "Animal study, Cyclotron, Quality control, Rubidium-82m",

author = "Pejman Rowshanfarzad and Jalilian, {Amir Reza} and Mohsen Kiyomarsi and Mahsheed Sabet and Karimian, {Ali Reza} and Sedigheh Moradkhani and Mohammad Mirzaii",

year = "2006",

month = nov,

day = "30",

language = "English",

volume = "51",

pages = "209--215",

journal = "Nukleonika",

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publisher = "Institute of Nuclear Chemistry and Technology",

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TY - JOUR

T1 - Production, quality control and initial imaging studies of [ 82mRb]RbCl for PET studies

AU - Rowshanfarzad, Pejman

AU - Jalilian, Amir Reza

AU - Kiyomarsi, Mohsen

AU - Sabet, Mahsheed

AU - Karimian, Ali Reza

AU - Moradkhani, Sedigheh

AU - Mirzaii, Mohammad

PY - 2006/11/30

Y1 - 2006/11/30

N2 - Rubidium-82m was prepared via 15.4 MeV proton irradiation of a krypton-82 gaseous target (30% enrichment). Washing the target chamber with hot water yielded a Rb-82m containing solution, which was further purified using short column chromatography in order to remove organic/inorganic impurities. The flowthrough was formulated in normal saline for injection. Radionuclide, radiochemical and chemical purity tests were performed prior to administration to rats for imaging (radiochemical yield: 95-97%, radiochemical purity > 97%). Preliminary dual-head coincidence studies were performed to determine the distribution of [82mRb]Rb in normal rats. For biodistribution studies, Rb-81 was injected to rats and tracer accumulation in heart, GI and bladder was determined after sacrification in time intervals. A yield of 1.3 GBq at EOB, 235.7 MBq/μAh was obtained.

AB - Rubidium-82m was prepared via 15.4 MeV proton irradiation of a krypton-82 gaseous target (30% enrichment). Washing the target chamber with hot water yielded a Rb-82m containing solution, which was further purified using short column chromatography in order to remove organic/inorganic impurities. The flowthrough was formulated in normal saline for injection. Radionuclide, radiochemical and chemical purity tests were performed prior to administration to rats for imaging (radiochemical yield: 95-97%, radiochemical purity > 97%). Preliminary dual-head coincidence studies were performed to determine the distribution of [82mRb]Rb in normal rats. For biodistribution studies, Rb-81 was injected to rats and tracer accumulation in heart, GI and bladder was determined after sacrification in time intervals. A yield of 1.3 GBq at EOB, 235.7 MBq/μAh was obtained.

KW - Animal study

KW - Cyclotron

KW - Quality control

KW - Rubidium-82m

UR - http://www.scopus.com/inward/record.url?scp=33751364271&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33751364271

SN - 0029-5922

VL - 51

SP - 209

EP - 215

JO - Nukleonika

JF - Nukleonika

IS - 4

ER -

Production, quality control and initial imaging studies of [ 82mRb]RbCl for PET studies

Abstract

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