Production of 75Se radioisotopes for nuclear medicine and labeling of odd cycle of [75Se]1,2,3-selenadiazole atom

Selenium-75 was prepared in no-carrier-added element form by proton bombardment of a compressed natural arsen ous trioxide disc. The chemical separation process was performed using solvent, solvent extraction method, which resulted in the extraction of selenium in organic phase. After the initial spectroscopic analysis, elemental selenium was oxidized to [75 Se] selenium dioxide and reacted with ethyl acetoacetate semicarbazone in acetic acid as the solvent to produce[75 Se]-5-ethoxycarbonyl-4-methyl-1,2,3-selena diazol as a prototype. The labeled compound was purified by chemical methods and quality control tests (radionuclidic, radiochemical, chemical purity and apyrogenicity-sterility tests) were performed, which confirmed the optimum purity of the final product