Production of 61Cu by the natZn(p,α) reaction: improved separation and specific activity determination by titration with three chelators

A.H. Asad; S.V. Smith; L.M. Morandeau; S. Chan; C.M. Jeffery; Roger Price

doi:10.1007/s10967-015-4412-y

Production of 61Cu by the natZn(p,α) reaction: improved separation and specific activity determination by titration with three chelators

A.H. Asad, S.V. Smith, L.M. Morandeau, S. Chan, C.M. Jeffery, Roger Price

Graduate Research School

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Abstract

© 2015, Akadémiai Kiadó, Budapest, Hungary. The cyclotron-based production of positron-emitting 61Cu using the (p,α) reaction at 11.7 MeV was investigated starting from natural-zinc (natZn) and enriched 64Zn-foil targets, as well as its subsequent purification. For natZn, a combination of three resins were assessed to separate 61Cu from contaminating 66,67,68Ga and natZn. The specific activity of the purified 61Cu determined using ICP-MS analysis ranged from 143.3 ± 14.3(SD) to 506.2 ± 50.6 MBq/µg while the titration method using p-SCN-Bn-DOTA, p-SCN-Bn-NOTA and diamsar gave variable results (4.7 ± 0.2–412.5 ± 15.3 MBq/µg), with diamsar lying closest to the ICP-MS values. Results suggest that the p-SCN-Bn-DOTA and p-SCN-Bn-NOTA titration methods are significantly affected by the presence of trace-metal contaminants.

Original language	English
Pages (from-to)	899-906
Number of pages	8
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	307
Issue number	2
DOIs	https://doi.org/10.1007/s10967-015-4412-y
Publication status	Published - 1 Feb 2016

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@article{4ac08a37442b4cbeb96e2e94f3606d6a,

title = "Production of 61Cu by the natZn(p,α) reaction: improved separation and specific activity determination by titration with three chelators",

abstract = "{\textcopyright} 2015, Akad{\'e}miai Kiad{\'o}, Budapest, Hungary. The cyclotron-based production of positron-emitting 61Cu using the (p,α) reaction at 11.7 MeV was investigated starting from natural-zinc (natZn) and enriched 64Zn-foil targets, as well as its subsequent purification. For natZn, a combination of three resins were assessed to separate 61Cu from contaminating 66,67,68Ga and natZn. The specific activity of the purified 61Cu determined using ICP-MS analysis ranged from 143.3 ± 14.3(SD) to 506.2 ± 50.6 MBq/µg while the titration method using p-SCN-Bn-DOTA, p-SCN-Bn-NOTA and diamsar gave variable results (4.7 ± 0.2–412.5 ± 15.3 MBq/µg), with diamsar lying closest to the ICP-MS values. Results suggest that the p-SCN-Bn-DOTA and p-SCN-Bn-NOTA titration methods are significantly affected by the presence of trace-metal contaminants.",

author = "A.H. Asad and S.V. Smith and L.M. Morandeau and S. Chan and C.M. Jeffery and Roger Price",

year = "2016",

month = feb,

day = "1",

doi = "10.1007/s10967-015-4412-y",

language = "English",

volume = "307",

pages = "899--906",

journal = "Journal of Radioanalytical and Nuclear Chemistry",

issn = "0236-5731",

publisher = "Springer",

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}

TY - JOUR

T1 - Production of 61Cu by the natZn(p,α) reaction: improved separation and specific activity determination by titration with three chelators

AU - Asad, A.H.

AU - Smith, S.V.

AU - Morandeau, L.M.

AU - Chan, S.

AU - Jeffery, C.M.

AU - Price, Roger

PY - 2016/2/1

Y1 - 2016/2/1

N2 - © 2015, Akadémiai Kiadó, Budapest, Hungary. The cyclotron-based production of positron-emitting 61Cu using the (p,α) reaction at 11.7 MeV was investigated starting from natural-zinc (natZn) and enriched 64Zn-foil targets, as well as its subsequent purification. For natZn, a combination of three resins were assessed to separate 61Cu from contaminating 66,67,68Ga and natZn. The specific activity of the purified 61Cu determined using ICP-MS analysis ranged from 143.3 ± 14.3(SD) to 506.2 ± 50.6 MBq/µg while the titration method using p-SCN-Bn-DOTA, p-SCN-Bn-NOTA and diamsar gave variable results (4.7 ± 0.2–412.5 ± 15.3 MBq/µg), with diamsar lying closest to the ICP-MS values. Results suggest that the p-SCN-Bn-DOTA and p-SCN-Bn-NOTA titration methods are significantly affected by the presence of trace-metal contaminants.

AB - © 2015, Akadémiai Kiadó, Budapest, Hungary. The cyclotron-based production of positron-emitting 61Cu using the (p,α) reaction at 11.7 MeV was investigated starting from natural-zinc (natZn) and enriched 64Zn-foil targets, as well as its subsequent purification. For natZn, a combination of three resins were assessed to separate 61Cu from contaminating 66,67,68Ga and natZn. The specific activity of the purified 61Cu determined using ICP-MS analysis ranged from 143.3 ± 14.3(SD) to 506.2 ± 50.6 MBq/µg while the titration method using p-SCN-Bn-DOTA, p-SCN-Bn-NOTA and diamsar gave variable results (4.7 ± 0.2–412.5 ± 15.3 MBq/µg), with diamsar lying closest to the ICP-MS values. Results suggest that the p-SCN-Bn-DOTA and p-SCN-Bn-NOTA titration methods are significantly affected by the presence of trace-metal contaminants.

U2 - 10.1007/s10967-015-4412-y

DO - 10.1007/s10967-015-4412-y

M3 - Article

SN - 0236-5731

VL - 307

SP - 899

EP - 906

JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 2

ER -

Production of 61Cu by the natZn(p,α) reaction: improved separation and specific activity determination by titration with three chelators

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