Production of 61Cu by the natZn(p,α) reaction: improved separation and specific activity determination by titration with three chelators

A.H. Asad, S.V. Smith, L.M. Morandeau, S. Chan, C.M. Jeffery, Roger Price

Research output: Contribution to journalArticlepeer-review

8 Citations (Web of Science)

Abstract

© 2015, Akadémiai Kiadó, Budapest, Hungary. The cyclotron-based production of positron-emitting 61Cu using the (p,α) reaction at 11.7 MeV was investigated starting from natural-zinc (natZn) and enriched 64Zn-foil targets, as well as its subsequent purification. For natZn, a combination of three resins were assessed to separate 61Cu from contaminating 66,67,68Ga and natZn. The specific activity of the purified 61Cu determined using ICP-MS analysis ranged from 143.3 ± 14.3(SD) to 506.2 ± 50.6 MBq/µg while the titration method using p-SCN-Bn-DOTA, p-SCN-Bn-NOTA and diamsar gave variable results (4.7 ± 0.2–412.5 ± 15.3 MBq/µg), with diamsar lying closest to the ICP-MS values. Results suggest that the p-SCN-Bn-DOTA and p-SCN-Bn-NOTA titration methods are significantly affected by the presence of trace-metal contaminants.
Original languageEnglish
Pages (from-to)899-906
Number of pages8
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume307
Issue number2
DOIs
Publication statusPublished - 1 Feb 2016

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