Production, formulation, quality control and primary biological studies on [18F]KF for skeletal PET scanning

Amir Reza Jalilian; Mohammad Mirzaii; Pejman Rowshan Farzad; Mohammad Reza Ensaf; Alireza Karimian; Gholamreza Aslani; Farahnaz Motamedi-Sedeh; Mehraban Pooladi; Behrouz Shirazi; Hossein Afarideh; Saeed Daneshvari

Production, formulation, quality control and primary biological studies on [18F]KF for skeletal PET scanning

Amir Reza Jalilian, Mohammad Mirzaii, Pejman Rowshan Farzad, Mohammad Reza Ensaf, Alireza Karimian, Gholamreza Aslani, Farahnaz Motamedi-Sedeh, Mehraban Pooladi, Behrouz Shirazi, Hossein Afarideh, Saeed Daneshvari

School of Physics, Mathematics and Computing

Research output: Contribution to journal › Article › peer-review

Abstract

[18F]KF, considered as a reference standard for positron emission tomography of the skeletal system, was produced by the bombardment of enriched water ([18O]H2O>95%) with high energy protons in NRCAM cyclotron. After the extraction of fluoride from enriched water as KF, and passing it through microbial filter and fine adjustment of acidity and osmolality, it was converted into an injectable form. Pre-clinical investigations and biological controls were performed to determine radioisotope distribution in laboratory rats, thus suitable information was gathered for imaging in humans. This radiopharmaceutical was proved to be quite safe and of high quality as a result of testing in laboratory rats.

Original language	Other
Pages (from-to)	49-61
Number of pages	12
Journal	Iranian Journal of Nuclear Medicine
Volume	12
Issue number	1
Publication status	Published - 2003

Access to Document

http://irjnm.tums.ac.ir/article_439_0cc517d9f5495c872885b26a609a155b.pdfLicence: Other

Cite this

Jalilian, A. R., Mirzaii, M., Rowshan Farzad, P., Ensaf, M. R., Karimian, A., Aslani, G., Motamedi-Sedeh, F., Pooladi, M., Shirazi, B., Afarideh, H., & Daneshvari, S. (2003). Production, formulation, quality control and primary biological studies on [18F]KF for skeletal PET scanning. Iranian Journal of Nuclear Medicine, 12(1), 49-61. http://irjnm.tums.ac.ir/article_439_0cc517d9f5495c872885b26a609a155b.pdf

@article{decb4fbf420d4492a31b96be505c7e33,

title = "Production, formulation, quality control and primary biological studies on [18F]KF for skeletal PET scanning",

abstract = "[18F]KF, considered as a reference standard for positron emission tomography of the skeletal system, was produced by the bombardment of enriched water ([18O]H2O>95\%) with high energy protons in NRCAM cyclotron. After the extraction of fluoride from enriched water as KF, and passing it through microbial filter and fine adjustment of acidity and osmolality, it was converted into an injectable form. Pre-clinical investigations and biological controls were performed to determine radioisotope distribution in laboratory rats, thus suitable information was gathered for imaging in humans. This radiopharmaceutical was proved to be quite safe and of high quality as a result of testing in laboratory rats.",

author = "Jalilian, \{Amir Reza\} and Mohammad Mirzaii and \{Rowshan Farzad\}, Pejman and Ensaf, \{Mohammad Reza\} and Alireza Karimian and Gholamreza Aslani and Farahnaz Motamedi-Sedeh and Mehraban Pooladi and Behrouz Shirazi and Hossein Afarideh and Saeed Daneshvari",

year = "2003",

language = "Other",

volume = "12",

pages = "49--61",

journal = "Iranian Journal of Nuclear Medicine",

issn = "1681-2824",

publisher = "Tehran University of Medical Sciences",

number = "1",

}

Jalilian, AR, Mirzaii, M, Rowshan Farzad, P, Ensaf, MR, Karimian, A, Aslani, G, Motamedi-Sedeh, F, Pooladi, M, Shirazi, B, Afarideh, H & Daneshvari, S 2003, 'Production, formulation, quality control and primary biological studies on [18F]KF for skeletal PET scanning', Iranian Journal of Nuclear Medicine, vol. 12, no. 1, pp. 49-61. <http://irjnm.tums.ac.ir/article_439_0cc517d9f5495c872885b26a609a155b.pdf>

TY - JOUR

T1 - Production, formulation, quality control and primary biological studies on [18F]KF for skeletal PET scanning

AU - Jalilian, Amir Reza

AU - Mirzaii, Mohammad

AU - Rowshan Farzad, Pejman

AU - Ensaf, Mohammad Reza

AU - Karimian, Alireza

AU - Aslani, Gholamreza

AU - Motamedi-Sedeh, Farahnaz

AU - Pooladi, Mehraban

AU - Shirazi, Behrouz

AU - Afarideh, Hossein

AU - Daneshvari, Saeed

PY - 2003

Y1 - 2003

N2 - [18F]KF, considered as a reference standard for positron emission tomography of the skeletal system, was produced by the bombardment of enriched water ([18O]H2O>95%) with high energy protons in NRCAM cyclotron. After the extraction of fluoride from enriched water as KF, and passing it through microbial filter and fine adjustment of acidity and osmolality, it was converted into an injectable form. Pre-clinical investigations and biological controls were performed to determine radioisotope distribution in laboratory rats, thus suitable information was gathered for imaging in humans. This radiopharmaceutical was proved to be quite safe and of high quality as a result of testing in laboratory rats.

AB - [18F]KF, considered as a reference standard for positron emission tomography of the skeletal system, was produced by the bombardment of enriched water ([18O]H2O>95%) with high energy protons in NRCAM cyclotron. After the extraction of fluoride from enriched water as KF, and passing it through microbial filter and fine adjustment of acidity and osmolality, it was converted into an injectable form. Pre-clinical investigations and biological controls were performed to determine radioisotope distribution in laboratory rats, thus suitable information was gathered for imaging in humans. This radiopharmaceutical was proved to be quite safe and of high quality as a result of testing in laboratory rats.

M3 - Article

SN - 1681-2824

VL - 12

SP - 49

EP - 61

JO - Iranian Journal of Nuclear Medicine

JF - Iranian Journal of Nuclear Medicine

IS - 1

ER -