Production and tumour uptake of [64Cu]pyruvaldehyde-bis (N 4-methylthiosemicarbazone) for PET and/or therapeutic purposes

Amir Reza Jalilian, Pejman Rowshanfarzad, Yousef Yari Kamrani, Kamaleddin Shafaii, Mohammad Mirzaii

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

BACKGROUND: Copper-64 (T1/2 = 12.7°h) is an important radionuclide used both in PET imaging and therapy. [64Cu]- pyruvaldehyde-bis(N4-methylthiosemicarbazone) ([64Cu]- PTSM) has already been used in the detection of cerebral and myocardial blood flow. In this study, a simple production method and tumour accumulation of [64Cu]-PTSM in fibrosarcoma-bearing mice were reported. MATERIAL AND METHODS: Cu-64 was produced via the 68Zn(p, αn)64Cu nuclear reaction. [64Cu]-PTSM was prepared using in-house made PTSM ligand and [64Cu]cuprous acetate and injected to fibrosarcoma-bearing mice. RESULTS: Copper-64 was prepared in chloride form (≈200 mCi, > 95% chemical yield at 180° μA for 1.1 h irradiation, radionuclidic purity μ 96%, copper-67 as impurity). The solution of 64Cu-PTSM was prepared in μ 80% radiochemical yield and more than 98% radiochemical purity. A significant tumour uptake was observed 2 hours post injection in tumour-bearing mice (tumour/muscle: 9, tumour/blood: 6). CONCLUSION: [ 64Cu]-PTSM was prepared on a radiopharmaceutical scale using readily available zinc-68, with high quality and was shown to possess application in the therapy and/or imaging of fibrosarcoma.

Original languageEnglish
Pages (from-to)6-11
Number of pages6
JournalNuclear Medicine Review
Volume10
Issue number1
Publication statusPublished - 1 Dec 2007

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