Probiotic Supplementation for Neonates with congenital Gastrointestinal Surgical Conditions

Research output: ThesisDoctoral Thesis

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Abstract

Neonates with congenital gastrointestinal surgical conditions (CGISCs) are at risk of gut dysbiosis, infections and suboptimal neurodevelopment. There is biological plausibility that attenuating dysbiosis may improve their outcomes. Our prospective study (n=73) found that compared to healthy infants, neonates with CGISCs had lower levels of stool bifidobacteria and biologically important short-chain fatty acids (SCFA). Hence, we conducted a pilot RCT (n=61), which found that bifidobacteria (probiotic) supplementation attenuated dysbiosis, and improved stool SCFA levels and head growth. We then provided guidelines for conducting large RCTs to evaluate the role of probiotics in improving their clinical and neurodevelopmental outcomes.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Patole, Sanjay, Supervisor
  • Simmer, Karen, Supervisor
Thesis sponsors
Award date25 May 2022
DOIs
Publication statusUnpublished - 2022

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