Oxidative stress is a feature of multiple pathological conditions (e.g. diabetes, cardiovascular diseases, and muscular dystrophies) and physiological perturbations such as ageing and physical exercise. Thiol groups found in proteins are particularly prone to oxidative modifications. The overall aim of this thesis is to develop several proteomic approaches, using different molecular probes, to investigate thiol containing proteins in mammalian tissues such as muscles and blood. Of note, multiple thiol-containing proteins were discovered in blood. This is of interest because these thiol containing proteins are potentially useful as biomarkers to monitor disease severity and efficacy of treatments.
|Qualification||Doctor of Philosophy|
|Award date||26 Mar 2021|
|Publication status||Unpublished - 2020|
- Embargoed from 26/03/2021 to 01/01/2023. Made publicly available on 01/01/2023.