Probing protein thiol proteomes for biomarkers of oxidative stress

Research output: ThesisDoctoral Thesis

87 Downloads (Pure)

Abstract

Oxidative stress is a feature of multiple pathological conditions (e.g. diabetes, cardiovascular diseases, and muscular dystrophies) and physiological perturbations such as ageing and physical exercise. Thiol groups found in proteins are particularly prone to oxidative modifications. The overall aim of this thesis is to develop several proteomic approaches, using different molecular probes, to investigate thiol containing proteins in mammalian tissues such as muscles and blood. Of note, multiple thiol-containing proteins were discovered in blood. This is of interest because these thiol containing proteins are potentially useful as biomarkers to monitor disease severity and efficacy of treatments.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Arthur, Peter, Supervisor
  • Grounds, Miranda, Supervisor
  • Terrill, Jessica, Supervisor
  • Bringans, Scott D., Supervisor, External person
Thesis sponsors
Award date26 Mar 2021
DOIs
Publication statusUnpublished - 2020

Embargo information

  • Embargoed from 26/03/2021 to 01/01/2023. Made publicly available on 01/01/2023.

Fingerprint

Dive into the research topics of 'Probing protein thiol proteomes for biomarkers of oxidative stress'. Together they form a unique fingerprint.

Cite this