Probing protein thiol proteomes for biomarkers of oxidative stress

Marisa Duong

doi:10.26182/z8fs-ct35

Probing protein thiol proteomes for biomarkers of oxidative stress

Marisa Duong

Research output: Thesis › Doctoral Thesis

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Abstract

Oxidative stress is a feature of multiple pathological conditions (e.g. diabetes, cardiovascular diseases, and muscular dystrophies) and physiological perturbations such as ageing and physical exercise. Thiol groups found in proteins are particularly prone to oxidative modifications. The overall aim of this thesis is to develop several proteomic approaches, using different molecular probes, to investigate thiol containing proteins in mammalian tissues such as muscles and blood. Of note, multiple thiol-containing proteins were discovered in blood. This is of interest because these thiol containing proteins are potentially useful as biomarkers to monitor disease severity and efficacy of treatments.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Arthur, Peter, Supervisor Grounds, Miranda, Supervisor Terrill, Jessica, Supervisor Bringans, Scott D., Supervisor, External person
Thesis sponsors	Australian Government Research Training Program
Award date	26 Mar 2021
DOIs	https://doi.org/10.26182/z8fs-ct35
Publication status	Unpublished - 2020

Embargo information

Embargoed from 26/03/2021 to 01/01/2023. Made publicly available on 01/01/2023.

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10.26182/z8fs-ct35

THESIS - DOCTOR OF PHILOSOPHY - DUONG, Nguyet Minh - 2020
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Cite this

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AB - Oxidative stress is a feature of multiple pathological conditions (e.g. diabetes, cardiovascular diseases, and muscular dystrophies) and physiological perturbations such as ageing and physical exercise. Thiol groups found in proteins are particularly prone to oxidative modifications. The overall aim of this thesis is to develop several proteomic approaches, using different molecular probes, to investigate thiol containing proteins in mammalian tissues such as muscles and blood. Of note, multiple thiol-containing proteins were discovered in blood. This is of interest because these thiol containing proteins are potentially useful as biomarkers to monitor disease severity and efficacy of treatments.

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Probing protein thiol proteomes for biomarkers of oxidative stress

Abstract

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