Primary tumor volume as a predictor of distant metastases and survival in patients with sinonasal mucosal melanoma

Stephanie Flukes; Shivangi Lohia; Christopher A Barker; Jennifer R Cracchiolo; Ian Ganly; Snehal G Patel; Benjamin R Roman; Jatin P Shah; Alexander N Shoushtari; Viviane Tabar; Akash Shah; Marc A Cohen

doi:10.1002/hed.26380

Primary tumor volume as a predictor of distant metastases and survival in patients with sinonasal mucosal melanoma

Stephanie Flukes, Shivangi Lohia, Christopher A Barker, Jennifer R Cracchiolo, Ian Ganly, Snehal G Patel, Benjamin R Roman, Jatin P Shah, Alexander N Shoushtari, Viviane Tabar, Akash Shah, Marc A Cohen

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

BACKGROUND: Sinonasal mucosal melanoma (SNMM) is an aggressive cancer with high mortality. Identifying patients at risk of distant metastasis assists with management and prognostication. We aimed to define the relationship between volume, survival, and risk of distant metastases.

METHODS: A retrospective review of all patients with SNMM treated at a single institution over a 21-year period was conducted. Tumor volume was calculated using cross-sectional imaging and survival analysis was performed.

RESULTS: Sixty-one patients were included. Tumor volume was predictive of local progression-free survival (P = .03), distant metastases-free survival (DMFS) (P = .002), and overall survival (OS) (P = .02). It was a better predictor than AJCC stage and T-classification. Tumor volume equal to or greater than 5 cm3 was associated with a significantly worse DMFS and OS (P = .02 and .009, respectively).

CONCLUSION: Calculation of tumor volume assists in quantifying the risk of distant metastases and death in SNMM.

Original language	English
Pages (from-to)	3316-3325
Number of pages	10
Journal	Head & neck
Volume	42
Issue number	11
DOIs	https://doi.org/10.1002/hed.26380
Publication status	Published - 1 Nov 2020
Externally published	Yes

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title = "Primary tumor volume as a predictor of distant metastases and survival in patients with sinonasal mucosal melanoma",

abstract = "BACKGROUND: Sinonasal mucosal melanoma (SNMM) is an aggressive cancer with high mortality. Identifying patients at risk of distant metastasis assists with management and prognostication. We aimed to define the relationship between volume, survival, and risk of distant metastases.METHODS: A retrospective review of all patients with SNMM treated at a single institution over a 21-year period was conducted. Tumor volume was calculated using cross-sectional imaging and survival analysis was performed.RESULTS: Sixty-one patients were included. Tumor volume was predictive of local progression-free survival (P = .03), distant metastases-free survival (DMFS) (P = .002), and overall survival (OS) (P = .02). It was a better predictor than AJCC stage and T-classification. Tumor volume equal to or greater than 5 cm3 was associated with a significantly worse DMFS and OS (P = .02 and .009, respectively).CONCLUSION: Calculation of tumor volume assists in quantifying the risk of distant metastases and death in SNMM.",

keywords = "Humans, Melanoma/pathology, Nasal Mucosa/pathology, Neoplasm Staging, Paranasal Sinus Neoplasms/diagnostic imaging, Prognosis, Retrospective Studies, Survival Rate, Tumor Burden",

author = "Stephanie Flukes and Shivangi Lohia and Barker, \{Christopher A\} and Cracchiolo, \{Jennifer R\} and Ian Ganly and Patel, \{Snehal G\} and Roman, \{Benjamin R\} and Shah, \{Jatin P\} and Shoushtari, \{Alexander N\} and Viviane Tabar and Akash Shah and Cohen, \{Marc A\}",

year = "2020",

month = nov,

day = "1",

doi = "10.1002/hed.26380",

language = "English",

volume = "42",

pages = "3316--3325",

journal = "Head \& neck",

issn = "1043-3074",

publisher = "John Wiley \& Sons",

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TY - JOUR

T1 - Primary tumor volume as a predictor of distant metastases and survival in patients with sinonasal mucosal melanoma

AU - Flukes, Stephanie

AU - Lohia, Shivangi

AU - Barker, Christopher A

AU - Cracchiolo, Jennifer R

AU - Ganly, Ian

AU - Patel, Snehal G

AU - Roman, Benjamin R

AU - Shah, Jatin P

AU - Shoushtari, Alexander N

AU - Tabar, Viviane

AU - Shah, Akash

AU - Cohen, Marc A

PY - 2020/11/1

Y1 - 2020/11/1

N2 - BACKGROUND: Sinonasal mucosal melanoma (SNMM) is an aggressive cancer with high mortality. Identifying patients at risk of distant metastasis assists with management and prognostication. We aimed to define the relationship between volume, survival, and risk of distant metastases.METHODS: A retrospective review of all patients with SNMM treated at a single institution over a 21-year period was conducted. Tumor volume was calculated using cross-sectional imaging and survival analysis was performed.RESULTS: Sixty-one patients were included. Tumor volume was predictive of local progression-free survival (P = .03), distant metastases-free survival (DMFS) (P = .002), and overall survival (OS) (P = .02). It was a better predictor than AJCC stage and T-classification. Tumor volume equal to or greater than 5 cm3 was associated with a significantly worse DMFS and OS (P = .02 and .009, respectively).CONCLUSION: Calculation of tumor volume assists in quantifying the risk of distant metastases and death in SNMM.

AB - BACKGROUND: Sinonasal mucosal melanoma (SNMM) is an aggressive cancer with high mortality. Identifying patients at risk of distant metastasis assists with management and prognostication. We aimed to define the relationship between volume, survival, and risk of distant metastases.METHODS: A retrospective review of all patients with SNMM treated at a single institution over a 21-year period was conducted. Tumor volume was calculated using cross-sectional imaging and survival analysis was performed.RESULTS: Sixty-one patients were included. Tumor volume was predictive of local progression-free survival (P = .03), distant metastases-free survival (DMFS) (P = .002), and overall survival (OS) (P = .02). It was a better predictor than AJCC stage and T-classification. Tumor volume equal to or greater than 5 cm3 was associated with a significantly worse DMFS and OS (P = .02 and .009, respectively).CONCLUSION: Calculation of tumor volume assists in quantifying the risk of distant metastases and death in SNMM.

KW - Humans

KW - Melanoma/pathology

KW - Nasal Mucosa/pathology

KW - Neoplasm Staging

KW - Paranasal Sinus Neoplasms/diagnostic imaging

KW - Prognosis

KW - Retrospective Studies

KW - Survival Rate

KW - Tumor Burden

UR - https://www.scopus.com/pages/publications/85088804046

U2 - 10.1002/hed.26380

DO - 10.1002/hed.26380

M3 - Article

C2 - 32737953

SN - 1043-3074

VL - 42

SP - 3316

EP - 3325

JO - Head & neck

JF - Head & neck

IS - 11

ER -

Primary tumor volume as a predictor of distant metastases and survival in patients with sinonasal mucosal melanoma

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