TY - JOUR
T1 - Primary antibiotic resistance of Helicobacter pylori among a Chinese Tibetan population
AU - Tang, Xiaoqiong
AU - Chen, Xiaohong
AU - Shen, Yalin
AU - Yang, Tiankuo
AU - Hu, Renwei
AU - Debowski, Aleksandra W.
AU - Stubbs, Keith A.
AU - Benghezal, Mohammed
AU - Marshall, Barry J.
AU - Li, Hong
AU - Tang, Hong
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Aim: To evaluate the primary antibiotic resistance in Helicobacter pylori strains isolated from a Chinese Tibetan population. Methods & materials: Gastric biopsies from 400 H. pylori treatment-naive Tibetan patients were collected for H. pylori isolation. Susceptibility to amoxicillin (AML)/clarithromycin (CLR)/levofloxacin (LEV)/metronidazole (MTZ)/tetracycline (TET)/rifampicin (RIF)/furazolidone (FZD) was determined by E-test or a disk diffusion assay. Results: Biopsies from 117 patients were H. pylori culture positive (29.3%). The primary resistance rates to MTZ, CLR, LEV, RIF, AML, TET and FZD were 90.6, 44.4, 28.2, 69.2, 7.7, 0.8 and 0.8%, respectively. Interestingly, 42.7% of the strains had simultaneous resistance to CLR and MTZ. Conclusion: Among Tibetan strains, primary resistance rates were high for CLR/MTZ/LEV, whereas primary resistance rates to AML/TET/FZD were low. The high resistance to RIF is a concerning finding.
AB - Aim: To evaluate the primary antibiotic resistance in Helicobacter pylori strains isolated from a Chinese Tibetan population. Methods & materials: Gastric biopsies from 400 H. pylori treatment-naive Tibetan patients were collected for H. pylori isolation. Susceptibility to amoxicillin (AML)/clarithromycin (CLR)/levofloxacin (LEV)/metronidazole (MTZ)/tetracycline (TET)/rifampicin (RIF)/furazolidone (FZD) was determined by E-test or a disk diffusion assay. Results: Biopsies from 117 patients were H. pylori culture positive (29.3%). The primary resistance rates to MTZ, CLR, LEV, RIF, AML, TET and FZD were 90.6, 44.4, 28.2, 69.2, 7.7, 0.8 and 0.8%, respectively. Interestingly, 42.7% of the strains had simultaneous resistance to CLR and MTZ. Conclusion: Among Tibetan strains, primary resistance rates were high for CLR/MTZ/LEV, whereas primary resistance rates to AML/TET/FZD were low. The high resistance to RIF is a concerning finding.
KW - antimicrobial susceptibility testing
KW - empiric therapy
KW - Helicobacter pylori
KW - rifampicin
KW - Tibetan population
UR - http://www.scopus.com/inward/record.url?scp=85094220230&partnerID=8YFLogxK
U2 - 10.2217/fmb-2020-0206
DO - 10.2217/fmb-2020-0206
M3 - Article
C2 - 32900223
AN - SCOPUS:85094220230
SN - 1746-0913
VL - 15
SP - 1353
EP - 1361
JO - Future Microbiology
JF - Future Microbiology
IS - 14
ER -