Primary and isolated anaplastic large cell lymphoma of the bone marrow

Emma Gudgin, J. Rashbass, K. J. Pulford, W. N. Erber

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Anaplastic large cell lymphoma (ALCL) is a T-cell lymphoma in which the majority of patients present with advanced stage III or IV disease. Here we report a case of ALCL where bone marrow was the only site of disease, in a 60-year-old man with pyrexia and pancytopenia. The diagnosis of ALCL was made on detection of CD30-positive anaplastic cells in the bone marrow, together with prominent hemophagocytosis. Genetics confirmed the clonal nature of the disease and showed it to be anaplastic lymphoma kinase (ALK) negative. Primary isolated bone marrow ALCL should be considered in the diagnosis of pancytopenia associated with hemophagocytosis.

Original languageEnglish
Pages (from-to)461-463
Number of pages3
JournalLeukemia and Lymphoma
Volume46
Issue number3
DOIs
Publication statusPublished - 1 Mar 2005
Externally publishedYes

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