Primary and isolated anaplastic large cell lymphoma of the bone marrow

Emma Gudgin; J. Rashbass; K. J. Pulford; W. N. Erber

doi:10.1080/10428190400011468

Primary and isolated anaplastic large cell lymphoma of the bone marrow

Emma Gudgin, J. Rashbass, K. J. Pulford, W. N. Erber

Research output: Contribution to journal › Article › peer-review

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Abstract

Anaplastic large cell lymphoma (ALCL) is a T-cell lymphoma in which the majority of patients present with advanced stage III or IV disease. Here we report a case of ALCL where bone marrow was the only site of disease, in a 60-year-old man with pyrexia and pancytopenia. The diagnosis of ALCL was made on detection of CD30-positive anaplastic cells in the bone marrow, together with prominent hemophagocytosis. Genetics confirmed the clonal nature of the disease and showed it to be anaplastic lymphoma kinase (ALK) negative. Primary isolated bone marrow ALCL should be considered in the diagnosis of pancytopenia associated with hemophagocytosis.

Original language	English
Pages (from-to)	461-463
Number of pages	3
Journal	Leukemia and Lymphoma
Volume	46
Issue number	3
DOIs	https://doi.org/10.1080/10428190400011468
Publication status	Published - 1 Mar 2005
Externally published	Yes

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title = "Primary and isolated anaplastic large cell lymphoma of the bone marrow",

abstract = "Anaplastic large cell lymphoma (ALCL) is a T-cell lymphoma in which the majority of patients present with advanced stage III or IV disease. Here we report a case of ALCL where bone marrow was the only site of disease, in a 60-year-old man with pyrexia and pancytopenia. The diagnosis of ALCL was made on detection of CD30-positive anaplastic cells in the bone marrow, together with prominent hemophagocytosis. Genetics confirmed the clonal nature of the disease and showed it to be anaplastic lymphoma kinase (ALK) negative. Primary isolated bone marrow ALCL should be considered in the diagnosis of pancytopenia associated with hemophagocytosis.",

keywords = "Anaplastic large cell lymphoma, Anaplastic lymphoma kinase (ALK), Bone marrow, Hemophagocytosis, Pancytopenia",

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T1 - Primary and isolated anaplastic large cell lymphoma of the bone marrow

AU - Gudgin, Emma

AU - Rashbass, J.

AU - Pulford, K. J.

AU - Erber, W. N.

PY - 2005/3/1

Y1 - 2005/3/1

N2 - Anaplastic large cell lymphoma (ALCL) is a T-cell lymphoma in which the majority of patients present with advanced stage III or IV disease. Here we report a case of ALCL where bone marrow was the only site of disease, in a 60-year-old man with pyrexia and pancytopenia. The diagnosis of ALCL was made on detection of CD30-positive anaplastic cells in the bone marrow, together with prominent hemophagocytosis. Genetics confirmed the clonal nature of the disease and showed it to be anaplastic lymphoma kinase (ALK) negative. Primary isolated bone marrow ALCL should be considered in the diagnosis of pancytopenia associated with hemophagocytosis.

AB - Anaplastic large cell lymphoma (ALCL) is a T-cell lymphoma in which the majority of patients present with advanced stage III or IV disease. Here we report a case of ALCL where bone marrow was the only site of disease, in a 60-year-old man with pyrexia and pancytopenia. The diagnosis of ALCL was made on detection of CD30-positive anaplastic cells in the bone marrow, together with prominent hemophagocytosis. Genetics confirmed the clonal nature of the disease and showed it to be anaplastic lymphoma kinase (ALK) negative. Primary isolated bone marrow ALCL should be considered in the diagnosis of pancytopenia associated with hemophagocytosis.

KW - Anaplastic large cell lymphoma

KW - Anaplastic lymphoma kinase (ALK)

KW - Bone marrow

KW - Hemophagocytosis

KW - Pancytopenia

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DO - 10.1080/10428190400011468

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AN - SCOPUS:13544260856

SN - 1042-8194

VL - 46

SP - 461

EP - 463

JO - Leukemia and Lymphoma

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Primary and isolated anaplastic large cell lymphoma of the bone marrow

Abstract

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