TY - JOUR
T1 - Primary acute dengue and the deletion in chemokine receptor 5 (CCR5δ32)
AU - Brestovac, B.
AU - Halicki, L.A.
AU - Harris, R.P.
AU - Sampson, I.
AU - Speers, David
AU - Mamotte, C.
AU - Williams, D.T.
PY - 2014
Y1 - 2014
N2 - Dengue virus is a significant arboviral pathogen that is continuing to spread due to human travel and invasion of the mosquito vectors into new regions. Chemokine receptor 5 (CCR5) has a truncated 32 base pair deletion form (CCR5δ32), which has been associated with resistance to HIV but increased severity in some flaviviral diseases. If CCR5δ32 is associated with dengue, European carriers of this mutation may be at increased risk. In a Western Australian population with the same frequency of CCR5δ32 (0.08) as that found in southern Europe there was no significant difference in CCR5δ32 allele frequency between returned travellers with and without dengue (p=0.82, OR=0.86, 95% CI=0.35-2.1). © 2014 Institut Pasteur.
AB - Dengue virus is a significant arboviral pathogen that is continuing to spread due to human travel and invasion of the mosquito vectors into new regions. Chemokine receptor 5 (CCR5) has a truncated 32 base pair deletion form (CCR5δ32), which has been associated with resistance to HIV but increased severity in some flaviviral diseases. If CCR5δ32 is associated with dengue, European carriers of this mutation may be at increased risk. In a Western Australian population with the same frequency of CCR5δ32 (0.08) as that found in southern Europe there was no significant difference in CCR5δ32 allele frequency between returned travellers with and without dengue (p=0.82, OR=0.86, 95% CI=0.35-2.1). © 2014 Institut Pasteur.
U2 - 10.1016/j.micinf.2014.02.007
DO - 10.1016/j.micinf.2014.02.007
M3 - Article
C2 - 24607451
SN - 1286-4579
VL - 16
SP - 518
EP - 521
JO - Microbes and Infection
JF - Microbes and Infection
IS - 6
ER -
