Prevention of infectious diseases by public vaccination and individual protection

Xiao Long Peng, Xin Jian Xu, Michael Small, Xinchu Fu, Zhen Jin

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    18 Citations (Scopus)
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    Abstract

    In the face of serious infectious diseases, governments endeavour to implement containment measures such as public vaccination at a macroscopic level. Meanwhile, individuals tend to protect themselves by avoiding contacts with infections at a microscopic level. However, a comprehensive understanding of how such combined strategy influences epidemic dynamics is still lacking. We study a susceptible-infected-susceptible epidemic model with imperfect vaccination on dynamic contact networks, where the macroscopic intervention is represented by random vaccination of the population and the microscopic protection is characterised by susceptible individuals rewiring contacts from infective neighbours. In particular, the model is formulated both in populations without and then with demographic effects (births, deaths, and migration). Using the pairwise approximation and the probability generating function approach, we investigate both dynamics of the epidemic and the underlying network. For populations without demography, the emerging degree correlations, bistable states, and oscillations demonstrate the combined effects of the public vaccination program and individual protective behavior. Compared to either strategy in isolation, the combination of public vaccination and individual protection is more effective in preventing and controlling the spread of infectious diseases by increasing both the invasion threshold and the persistence threshold. For populations with additional demographic factors, we investigate temporal evolution of infected individuals and infectious contacts, as well as degree distributions of nodes in each class. It is found that the disease spreads faster but is more restricted in scale-free networks than in the Erdös-RÃ

    Original languageEnglish
    Pages (from-to)1561-1594
    Number of pages34
    JournalJournal of Mathematical Biology
    Volume73
    Issue number6-7
    Early online date15 Apr 2016
    DOIs
    Publication statusPublished - 1 Dec 2016

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