Prevention and treatment of necrotising enterocolitis in preterm neonates

    Research output: Contribution to journalReview article

    43 Citations (Scopus)

    Abstract

    Prevention and treatment of NEC has become an area of priority for research due to the increasing number of preterm survivors at risk, and the significant mortality and morbidity related to the illness. Probiotic supplementation appears to be a promising option for primary prevention of NEC but further Large trials are necessary for documenting their safety in terms of sepsis as well as long-term neurodevelopmental outcomes and immune function. As new frontiers including immunomodulating agents like pentoxifylline continue to be explored, the impact of well-established simple strategies like antenatal glucocorticoid therapy, and early and preferential use of breast milk must not be forgotten. Clinical research on manifestations of ileus of prematurity, and feeding in the presence of common risk factors such as IUGR is needed. Safety of minimal enteral feeds in terms of NEC and benefits of standardised feeding regimens need to be confirmed. Association of common clinical practices such as red cell transfusions, H2 receptor blockade, and thickening of feeds with NEC warrants attention. An approach utilising a package of potentially better practices seems to be the most appropriate strategy for the prevention and treatment of NEC. (C) 2007 Elsevier Ireland Ltd. ALL rights reserved.
    Original languageEnglish
    Pages (from-to)635-642
    JournalEarly Human Development
    Volume83
    DOIs
    Publication statusPublished - 2007

    Fingerprint

    Necrotizing Enterocolitis
    Newborn Infant
    Safety
    Pentoxifylline
    Histamine H2 Receptors
    Fetal Growth Retardation
    Ileus
    Probiotics
    Human Milk
    Primary Prevention
    Research
    Glucocorticoids
    Small Intestine
    Survivors
    Sepsis
    Therapeutics
    Morbidity
    Mortality

    Cite this

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    title = "Prevention and treatment of necrotising enterocolitis in preterm neonates",
    abstract = "Prevention and treatment of NEC has become an area of priority for research due to the increasing number of preterm survivors at risk, and the significant mortality and morbidity related to the illness. Probiotic supplementation appears to be a promising option for primary prevention of NEC but further Large trials are necessary for documenting their safety in terms of sepsis as well as long-term neurodevelopmental outcomes and immune function. As new frontiers including immunomodulating agents like pentoxifylline continue to be explored, the impact of well-established simple strategies like antenatal glucocorticoid therapy, and early and preferential use of breast milk must not be forgotten. Clinical research on manifestations of ileus of prematurity, and feeding in the presence of common risk factors such as IUGR is needed. Safety of minimal enteral feeds in terms of NEC and benefits of standardised feeding regimens need to be confirmed. Association of common clinical practices such as red cell transfusions, H2 receptor blockade, and thickening of feeds with NEC warrants attention. An approach utilising a package of potentially better practices seems to be the most appropriate strategy for the prevention and treatment of NEC. (C) 2007 Elsevier Ireland Ltd. ALL rights reserved.",
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    Prevention and treatment of necrotising enterocolitis in preterm neonates. / Patole, Sanjay.

    In: Early Human Development, Vol. 83, 2007, p. 635-642.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - Prevention and treatment of necrotising enterocolitis in preterm neonates

    AU - Patole, Sanjay

    PY - 2007

    Y1 - 2007

    N2 - Prevention and treatment of NEC has become an area of priority for research due to the increasing number of preterm survivors at risk, and the significant mortality and morbidity related to the illness. Probiotic supplementation appears to be a promising option for primary prevention of NEC but further Large trials are necessary for documenting their safety in terms of sepsis as well as long-term neurodevelopmental outcomes and immune function. As new frontiers including immunomodulating agents like pentoxifylline continue to be explored, the impact of well-established simple strategies like antenatal glucocorticoid therapy, and early and preferential use of breast milk must not be forgotten. Clinical research on manifestations of ileus of prematurity, and feeding in the presence of common risk factors such as IUGR is needed. Safety of minimal enteral feeds in terms of NEC and benefits of standardised feeding regimens need to be confirmed. Association of common clinical practices such as red cell transfusions, H2 receptor blockade, and thickening of feeds with NEC warrants attention. An approach utilising a package of potentially better practices seems to be the most appropriate strategy for the prevention and treatment of NEC. (C) 2007 Elsevier Ireland Ltd. ALL rights reserved.

    AB - Prevention and treatment of NEC has become an area of priority for research due to the increasing number of preterm survivors at risk, and the significant mortality and morbidity related to the illness. Probiotic supplementation appears to be a promising option for primary prevention of NEC but further Large trials are necessary for documenting their safety in terms of sepsis as well as long-term neurodevelopmental outcomes and immune function. As new frontiers including immunomodulating agents like pentoxifylline continue to be explored, the impact of well-established simple strategies like antenatal glucocorticoid therapy, and early and preferential use of breast milk must not be forgotten. Clinical research on manifestations of ileus of prematurity, and feeding in the presence of common risk factors such as IUGR is needed. Safety of minimal enteral feeds in terms of NEC and benefits of standardised feeding regimens need to be confirmed. Association of common clinical practices such as red cell transfusions, H2 receptor blockade, and thickening of feeds with NEC warrants attention. An approach utilising a package of potentially better practices seems to be the most appropriate strategy for the prevention and treatment of NEC. (C) 2007 Elsevier Ireland Ltd. ALL rights reserved.

    U2 - 10.1016/j.earlhumdev.2007.07.007

    DO - 10.1016/j.earlhumdev.2007.07.007

    M3 - Review article

    VL - 83

    SP - 635

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    JO - Early Human Development

    JF - Early Human Development

    SN - 0378-3782

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