Prevalence of suicide attempts in individuals with schizophrenia: A meta-analysis of observational studies

Li Lu, Min Dong, Ling Zhang, Xiao Min Zhu, Gabor S. Ungvari, Chee H. Ng, Gang Wang, Yu Tao Xiang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

AimsSuicide attempt is an important indicator of suicide and potential future mortality. However, the prevalence of suicide attempts has been inconsistent across studies. This meta-analysis aimed to examine the prevalence of suicide attempts in individuals with schizophrenia and associated correlates.MethodsRelevant publications in Embase, PsycINFO, PubMed, Web of science and Cochrane were systematically searched. Data on the prevalence of suicide attempts in individuals with schizophrenia were pooled using a random-effects model.ResultsThirty-five studies with 16 747 individuals with schizophrenia were included. The pooled lifetime prevalence of suicide attempts was 26.8% (95% CI 22.1-31.9%; I2 = 97.0%), while the 1-year prevalence, 1-month prevalence and the prevalence of suicide attempts from illness onset were 3.0% (95% CI 2.3-3.7%; I2 = 95.6%), 2.7% (95% CI 2.1-3.4%; I2 = 78.5%) and 45.9% (95% CI 42.1-49.9%; I2 = 0), respectively. Earlier age of onset (Q = 4.38, p = 0.04), high-income countries (Q = 53.29, p < 0.001), North America and Europe and Central Asia (Q = 32.83, p < 0.001) were significantly associated with a higher prevalence of suicide attempts.ConclusionsSuicide attempts are common in individuals with schizophrenia, especially those with an early age of onset and living in high-income countries and regions. Regular screening and effective preventive measures should be implemented as part of the clinical care.

Original languageEnglish
JournalEpidemiology and Psychiatric Sciences
DOIs
Publication statusE-pub ahead of print - 7 Jun 2019

Fingerprint

Suicide
Observational Studies
Meta-Analysis
Schizophrenia
Age of Onset
Central Asia
North America
PubMed
Publications
Mortality

Cite this

@article{cc1bc8559f934dcfa84c4d827a6fb981,
title = "Prevalence of suicide attempts in individuals with schizophrenia: A meta-analysis of observational studies",
abstract = "AimsSuicide attempt is an important indicator of suicide and potential future mortality. However, the prevalence of suicide attempts has been inconsistent across studies. This meta-analysis aimed to examine the prevalence of suicide attempts in individuals with schizophrenia and associated correlates.MethodsRelevant publications in Embase, PsycINFO, PubMed, Web of science and Cochrane were systematically searched. Data on the prevalence of suicide attempts in individuals with schizophrenia were pooled using a random-effects model.ResultsThirty-five studies with 16 747 individuals with schizophrenia were included. The pooled lifetime prevalence of suicide attempts was 26.8{\%} (95{\%} CI 22.1-31.9{\%}; I2 = 97.0{\%}), while the 1-year prevalence, 1-month prevalence and the prevalence of suicide attempts from illness onset were 3.0{\%} (95{\%} CI 2.3-3.7{\%}; I2 = 95.6{\%}), 2.7{\%} (95{\%} CI 2.1-3.4{\%}; I2 = 78.5{\%}) and 45.9{\%} (95{\%} CI 42.1-49.9{\%}; I2 = 0), respectively. Earlier age of onset (Q = 4.38, p = 0.04), high-income countries (Q = 53.29, p < 0.001), North America and Europe and Central Asia (Q = 32.83, p < 0.001) were significantly associated with a higher prevalence of suicide attempts.ConclusionsSuicide attempts are common in individuals with schizophrenia, especially those with an early age of onset and living in high-income countries and regions. Regular screening and effective preventive measures should be implemented as part of the clinical care.",
keywords = "Meta-analysis, schizophrenia, suicide attempt",
author = "Li Lu and Min Dong and Ling Zhang and Zhu, {Xiao Min} and Ungvari, {Gabor S.} and Ng, {Chee H.} and Gang Wang and Xiang, {Yu Tao}",
year = "2019",
month = "6",
day = "7",
doi = "10.1017/S2045796019000313",
language = "English",
journal = "Epidemiology and Psychiatric Sciences",
issn = "1121-189X",
publisher = "Cambridge University Press",

}

Prevalence of suicide attempts in individuals with schizophrenia : A meta-analysis of observational studies. / Lu, Li; Dong, Min; Zhang, Ling; Zhu, Xiao Min; Ungvari, Gabor S.; Ng, Chee H.; Wang, Gang; Xiang, Yu Tao.

In: Epidemiology and Psychiatric Sciences, 07.06.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevalence of suicide attempts in individuals with schizophrenia

T2 - A meta-analysis of observational studies

AU - Lu, Li

AU - Dong, Min

AU - Zhang, Ling

AU - Zhu, Xiao Min

AU - Ungvari, Gabor S.

AU - Ng, Chee H.

AU - Wang, Gang

AU - Xiang, Yu Tao

PY - 2019/6/7

Y1 - 2019/6/7

N2 - AimsSuicide attempt is an important indicator of suicide and potential future mortality. However, the prevalence of suicide attempts has been inconsistent across studies. This meta-analysis aimed to examine the prevalence of suicide attempts in individuals with schizophrenia and associated correlates.MethodsRelevant publications in Embase, PsycINFO, PubMed, Web of science and Cochrane were systematically searched. Data on the prevalence of suicide attempts in individuals with schizophrenia were pooled using a random-effects model.ResultsThirty-five studies with 16 747 individuals with schizophrenia were included. The pooled lifetime prevalence of suicide attempts was 26.8% (95% CI 22.1-31.9%; I2 = 97.0%), while the 1-year prevalence, 1-month prevalence and the prevalence of suicide attempts from illness onset were 3.0% (95% CI 2.3-3.7%; I2 = 95.6%), 2.7% (95% CI 2.1-3.4%; I2 = 78.5%) and 45.9% (95% CI 42.1-49.9%; I2 = 0), respectively. Earlier age of onset (Q = 4.38, p = 0.04), high-income countries (Q = 53.29, p < 0.001), North America and Europe and Central Asia (Q = 32.83, p < 0.001) were significantly associated with a higher prevalence of suicide attempts.ConclusionsSuicide attempts are common in individuals with schizophrenia, especially those with an early age of onset and living in high-income countries and regions. Regular screening and effective preventive measures should be implemented as part of the clinical care.

AB - AimsSuicide attempt is an important indicator of suicide and potential future mortality. However, the prevalence of suicide attempts has been inconsistent across studies. This meta-analysis aimed to examine the prevalence of suicide attempts in individuals with schizophrenia and associated correlates.MethodsRelevant publications in Embase, PsycINFO, PubMed, Web of science and Cochrane were systematically searched. Data on the prevalence of suicide attempts in individuals with schizophrenia were pooled using a random-effects model.ResultsThirty-five studies with 16 747 individuals with schizophrenia were included. The pooled lifetime prevalence of suicide attempts was 26.8% (95% CI 22.1-31.9%; I2 = 97.0%), while the 1-year prevalence, 1-month prevalence and the prevalence of suicide attempts from illness onset were 3.0% (95% CI 2.3-3.7%; I2 = 95.6%), 2.7% (95% CI 2.1-3.4%; I2 = 78.5%) and 45.9% (95% CI 42.1-49.9%; I2 = 0), respectively. Earlier age of onset (Q = 4.38, p = 0.04), high-income countries (Q = 53.29, p < 0.001), North America and Europe and Central Asia (Q = 32.83, p < 0.001) were significantly associated with a higher prevalence of suicide attempts.ConclusionsSuicide attempts are common in individuals with schizophrenia, especially those with an early age of onset and living in high-income countries and regions. Regular screening and effective preventive measures should be implemented as part of the clinical care.

KW - Meta-analysis

KW - schizophrenia

KW - suicide attempt

UR - http://www.scopus.com/inward/record.url?scp=85066970130&partnerID=8YFLogxK

U2 - 10.1017/S2045796019000313

DO - 10.1017/S2045796019000313

M3 - Article

JO - Epidemiology and Psychiatric Sciences

JF - Epidemiology and Psychiatric Sciences

SN - 1121-189X

ER -