Prevalence of Major Depression and Its Associations With Demographic and Clinical Characteristics and Quality of Life in Chinese Patients With HBV-related Liver Diseases

Mei Liu, Lu Li, Su Jun Zheng, Jing Hua Zhao, Gabor S. Ungvari, Brian J. Hall, Zhong Ping Duan, Yu-Tao Xiang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND There are no data about the frequency of major depression in patients with liver disease related to Hepatitis B virus (HBV) in China. This study examined the prevalence of major depression and its clinical correlates and association with quality of life (QOL) in patients with HBV-related liver diseases. METHOD Altogether 634 patients with HBV-related liver diseases met study entry criteria and completed the survey. The diagnosis of major depression was established with the Mini International Neuropsychiatric Interview (MINI). Socio-demographic and clinical characteristics, Global Assessment of Functioning (GAF) and QOL were measured. RESULTS The prevalence of major depression was 6.4%. Multivariable logistic regression analyses revealed that insomnia (P = 0.01, OR = 5.5, 95%CI = 1.4–21.6) and global functioning (P < 0.001, OR = 0.6, 95% CI = 0.5–0.7) were independently associated with major depression. Major depression was associated with both poor physical (F (1, 634) = 4.0, P = 0.04) and mental QOL (F (1, 634) = 26.2, P < 0.001). CONCLUSIONS Given the negative impact of depression on patients’ QOL, more attempts should be made to identify and treat it in HBV-related diseases.

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalArchives of Psychiatric Nursing
Volume31
Issue number3
DOIs
Publication statusPublished - 1 Jun 2017

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