TY - JOUR
T1 - Prevalence of hepatitis D virus infection in HBsAg positive subjects in Iran
AU - Roshandel, Gholamreza
AU - Semnani, Shahryar
AU - Abdolahi, Nafiseh
AU - Keshtkar, Abbas Ali
AU - Besharat, Sima
AU - Joshaghani, Hamidreza
AU - Moradi, Abdolvahab
AU - Kalavi, Khodaberdi
AU - Jabbari, Ali
AU - Kabir, Mohammad Javad
AU - Hosseini, Seyed Ahmad
AU - Sedaqat, Seyed Mehdi
AU - Danesh, Ahmad
AU - Roshandel, Danial
AU - Hedayat-Mofidi, Seyed Mohammad
PY - 2007/5/15
Y1 - 2007/5/15
N2 - This study was carried out to determine the seroprevalence of hepatitis D virus among HBsAg positive individuals in the northeast part of Iran. One hundred thirty nine HBsAg positive subjects detected from a population based single stage cluster sampling in Golestan province of Iran were enrolled. All cases were evaluated for the presence of anti-HDV antibodies using commercially available ELISA kits. Logistic regression was used to determine the relationship between independent variables and HDV seropositivity. Of 139 cases, 68(48.9%) were males and 71(51.1%) were females. The mean age was 41.89±11.30 years (25-64 years). Anti-HDV antibody was positive in 8 (5.8%) subjects with female predominance (9.9% versus 1.5%, p = 0.06; odds ratio = 7.32, 95%CI: 0.87-61.23). No significant relationship was seen between anti-HDV seropositivity and demographic factors such as age, place of residence and marital status. These findings showed that HDV infection was endemic in Golestan province (northeast) of Iran. Seroprevalence of Anti-HDV in the present study was higher than some previous studies from other parts of Iran. Our results suggest that the prevalence of HBV/HDV co-infection in Iran has increased during the last decade. Therefore, practitioners and all health care managers should be made aware of the risk of dual infection with HBV and HDV.
AB - This study was carried out to determine the seroprevalence of hepatitis D virus among HBsAg positive individuals in the northeast part of Iran. One hundred thirty nine HBsAg positive subjects detected from a population based single stage cluster sampling in Golestan province of Iran were enrolled. All cases were evaluated for the presence of anti-HDV antibodies using commercially available ELISA kits. Logistic regression was used to determine the relationship between independent variables and HDV seropositivity. Of 139 cases, 68(48.9%) were males and 71(51.1%) were females. The mean age was 41.89±11.30 years (25-64 years). Anti-HDV antibody was positive in 8 (5.8%) subjects with female predominance (9.9% versus 1.5%, p = 0.06; odds ratio = 7.32, 95%CI: 0.87-61.23). No significant relationship was seen between anti-HDV seropositivity and demographic factors such as age, place of residence and marital status. These findings showed that HDV infection was endemic in Golestan province (northeast) of Iran. Seroprevalence of Anti-HDV in the present study was higher than some previous studies from other parts of Iran. Our results suggest that the prevalence of HBV/HDV co-infection in Iran has increased during the last decade. Therefore, practitioners and all health care managers should be made aware of the risk of dual infection with HBV and HDV.
KW - Hepatitis B
KW - Hepatitis D
KW - Iran
UR - http://www.scopus.com/inward/record.url?scp=34247194202&partnerID=8YFLogxK
U2 - 10.3923/pjbs.2007.1751.1754
DO - 10.3923/pjbs.2007.1751.1754
M3 - Article
C2 - 19086531
AN - SCOPUS:34247194202
SN - 1028-8880
VL - 10
SP - 1751
EP - 1754
JO - Pakistan Journal of Biological Sciences
JF - Pakistan Journal of Biological Sciences
IS - 10
ER -
