Projects per year
Abstract
There is a paucity of epidemiologic data examining the relationship between pulmonary hypertension (PH) and diabetes. The aim of this study was to determine prevalence, incidence and associates of PH complicating type 2 diabetes. Data from 1430 participants (mean age 65.5 years, 51.5% males) in the Fremantle Diabetes Study Phase 2 (FDS2) were linked with the National Echocar-diographic Database of Australia (NEDA) to ascertain the prevalence and incidence of PH (estimated right ventricular systolic pressure (eRVSP) >30 mmHg as a new suggested threshold or the conventional >40 mmHg) over a 12-year period. PH prevalence in FDS2 was compared with that in NEDA overall and a geographically close sub-population. Multivariable analyses identified associates of prevalent/incident PH in the FDS2 cohort. Of 275 FDS2 patients (19.2%) with pre-entry echocar-diography, 90 had eRVSP >30 mmHg and 35 had eRVSP >40 mmHg (prevalences 32.7% (95% CI 27.3–38.7%) and 12.7% (9.1–17.4%), respectively), rates that are 35–50% greater than national/local NEDA general population estimates. Moreover, 70 (5.0%) and 123 (9.2%) FDS2 participants were identified with incident PH at the respective eRVSP thresholds (incidence (95% CI) 7.6 (6.0–9.7) and 14.2 (11.8–17.0)/1000 person-years), paralleling data from recognised high-risk conditions such as systemic sclerosis. The baseline plasma N-terminal pro-brain natriuretic peptide concentration was the strongest independent associate of prevalent/incident PH. Approximately 1 in 8 people with type 2 diabetes have PH using the eRVSP >40 mmHg threshold. Its presence should be considered as part of regular clinical assessment of individuals with type 2 diabetes.
Original language | English |
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Article number | 4503 |
Journal | Journal of Clinical Medicine |
Volume | 10 |
Issue number | 19 |
DOIs | |
Publication status | Published - 1 Oct 2021 |
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- 4 Finished
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MRFF - Community-based studies of diabetes and infectious diseases
Davis, T. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/19 → 31/12/23
Project: Research
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Development of a multi-faceted diagnostic and predictive tool to characterise type of diabetes, therapeutic progression and outcome
Davis, T. (Investigator 01), Davis, W. (Investigator 02), Bruce, D. (Investigator 03), Chubb, S. (Investigator 04) & Hattersley, A. (Investigator 05)
NHMRC National Health and Medical Research Council
1/01/17 → 31/12/19
Project: Research
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The Fremantle Diabetes Study Phase II - A Community Based Study of Diabetes Care Control Complications & Cost
Davis, T. (Investigator 01), Bruce, D. (Investigator 02), Davis, W. (Investigator 03), Chubb, S. (Investigator 04), Starkstein, S. (Investigator 05), Clarke, P. (Investigator 06), McAullay, D. (Investigator 07) & Norman, P. (Investigator 08)
NHMRC National Health and Medical Research Council
1/01/13 → 31/12/18
Project: Research