Preterm neonates display altered plasmacytoid dendritic cell function and morphology

S. S. Schüller, K. Sadeghi, Lukas Wisgrill, A. Dangl, S. C. Diesner, A. R. Prusa, K. Klebermasz-Schrehof, S. Greber-Platzer, J. Neumüller, H. Helmer, P. Husslein, A. Pollak, A. Spittler, E. Förster-Waldl

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Bacterial and viral infections cause high rates of morbidity and mortality in premature newborns. In the setting of viral infection, pDCs play a key role as strong producers of IFN-α upon TLR9 activation. We analyzed pDC frequency, phenotype, morphology, and function in CB of preterm and term newborns in comparison with adults. Whereas all age groups show similar pDC numbers, BDCA-2, CD123, and TLR9 levels, the expression of BDCA-4 and capacity to produce IFN-α upon TLR9 challenge were decreased significantly in preterm neonates. Furthermore, we show by means of electron microscopy that pDCs from preterm newborns exhibit a distinct, "immature" morphology. Taken together, these findings suggest decreased functionality of pDCs in the premature newborn. The reduced capacity to produce IFN-α is likely to render such infants more susceptible to viral infections.

Original languageEnglish
Pages (from-to)781-788
Number of pages8
JournalJournal of Leukocyte Biology
Volume93
Issue number5
DOIs
Publication statusPublished - 1 Apr 2013
Externally publishedYes

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