Prescription of antipsychotic and concomitant medications for adult Asian schizophrenia patients: Findings of the 2016 Research on Asian Psychotropic Prescription Patterns (REAP) survey

Min Dong, Liang Nan Zeng, Qinge Zhang, Shu Yu Yang, Lian Yu Chen, Eunice Najoan, Roy Abraham Kallivayalil, Kittisak Viboonma, Ruzita Jamaluddin, Afzal Javed, Duong Thi Quynh Hoa, Hitoshi Iida, Kang Sim, Thiha Swe, Yan Ling He, Yongchon Park, Helal Uddin Ahmed, Angelo De Alwis, Helen F.K. Chiu, Norman Sartorius & 9 others Chay Hoon Tan, Mian Yoon Chong, Naotaka Shinfuku, Shih Ku Lin, Ajit Avasthi, Sandeep Grover, Chee H. Ng, Gabor S. Ungvari, Yu Tao Xiang

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Objective: Regular surveys are important to monitor the use of psychotropic medications in clinical practice. This study examined the psychotropic prescription patterns in adult Asian schizophrenia patients based on the data of the Research on Asian Psychotropic Prescription (REAP) 2016 survey. Methods: : This cross-sectional survey across 15 Asian countries/territories collected socio-demographic and clinical data with standardized procedures between March and May 2016. The socio-demographic and clinical characteristics of the patients were recorded with a standardized questionnaire. Results: Altogether 3,537 adult patients with schizophrenia were consecutively screened and enrolled in the survey. The mean age was 38.66 ± 11.55 years and 59.7% of the sample were male. The mean dose of antipsychotics in chlorpromazine equivalents (CPZeq) was 424 ± 376 mg/day; 31.3% and 80.8% received first- and second- generation antipsychotics, respectively and 42.6% had antipsychotic polypharmacy, 11.7% had antidepressants, 13.7% had mood stabilizers, 27.8% had benzodiazepines, and 45.6% had anticholinergics. Conclusions: Psychotropic prescription patterns in Asian adult patients with schizophrenia varied across countries. Regular surveys on psychotropic medications for schizophrenia are important to monitor pharmacotherapy practice in Asia.

Original languageEnglish
Pages (from-to)74-80
Number of pages7
JournalAsian Journal of Psychiatry
Volume45
DOIs
Publication statusPublished - 1 Oct 2019

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Antipsychotic Agents
Prescriptions
Schizophrenia
Research
Demography
Polypharmacy
Chlorpromazine
Cholinergic Antagonists
Benzodiazepines
Antidepressive Agents
Cross-Sectional Studies
Surveys and Questionnaires
Drug Therapy

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Dong, Min ; Zeng, Liang Nan ; Zhang, Qinge ; Yang, Shu Yu ; Chen, Lian Yu ; Najoan, Eunice ; Kallivayalil, Roy Abraham ; Viboonma, Kittisak ; Jamaluddin, Ruzita ; Javed, Afzal ; Hoa, Duong Thi Quynh ; Iida, Hitoshi ; Sim, Kang ; Swe, Thiha ; He, Yan Ling ; Park, Yongchon ; Ahmed, Helal Uddin ; De Alwis, Angelo ; Chiu, Helen F.K. ; Sartorius, Norman ; Tan, Chay Hoon ; Chong, Mian Yoon ; Shinfuku, Naotaka ; Lin, Shih Ku ; Avasthi, Ajit ; Grover, Sandeep ; Ng, Chee H. ; Ungvari, Gabor S. ; Xiang, Yu Tao. / Prescription of antipsychotic and concomitant medications for adult Asian schizophrenia patients : Findings of the 2016 Research on Asian Psychotropic Prescription Patterns (REAP) survey. In: Asian Journal of Psychiatry. 2019 ; Vol. 45. pp. 74-80.
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abstract = "Objective: Regular surveys are important to monitor the use of psychotropic medications in clinical practice. This study examined the psychotropic prescription patterns in adult Asian schizophrenia patients based on the data of the Research on Asian Psychotropic Prescription (REAP) 2016 survey. Methods: : This cross-sectional survey across 15 Asian countries/territories collected socio-demographic and clinical data with standardized procedures between March and May 2016. The socio-demographic and clinical characteristics of the patients were recorded with a standardized questionnaire. Results: Altogether 3,537 adult patients with schizophrenia were consecutively screened and enrolled in the survey. The mean age was 38.66 ± 11.55 years and 59.7{\%} of the sample were male. The mean dose of antipsychotics in chlorpromazine equivalents (CPZeq) was 424 ± 376 mg/day; 31.3{\%} and 80.8{\%} received first- and second- generation antipsychotics, respectively and 42.6{\%} had antipsychotic polypharmacy, 11.7{\%} had antidepressants, 13.7{\%} had mood stabilizers, 27.8{\%} had benzodiazepines, and 45.6{\%} had anticholinergics. Conclusions: Psychotropic prescription patterns in Asian adult patients with schizophrenia varied across countries. Regular surveys on psychotropic medications for schizophrenia are important to monitor pharmacotherapy practice in Asia.",
keywords = "Antipsychotics, Asia, Prescription patterns, Schizophrenia",
author = "Min Dong and Zeng, {Liang Nan} and Qinge Zhang and Yang, {Shu Yu} and Chen, {Lian Yu} and Eunice Najoan and Kallivayalil, {Roy Abraham} and Kittisak Viboonma and Ruzita Jamaluddin and Afzal Javed and Hoa, {Duong Thi Quynh} and Hitoshi Iida and Kang Sim and Thiha Swe and He, {Yan Ling} and Yongchon Park and Ahmed, {Helal Uddin} and {De Alwis}, Angelo and Chiu, {Helen F.K.} and Norman Sartorius and Tan, {Chay Hoon} and Chong, {Mian Yoon} and Naotaka Shinfuku and Lin, {Shih Ku} and Ajit Avasthi and Sandeep Grover and Ng, {Chee H.} and Ungvari, {Gabor S.} and Xiang, {Yu Tao}",
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Dong, M, Zeng, LN, Zhang, Q, Yang, SY, Chen, LY, Najoan, E, Kallivayalil, RA, Viboonma, K, Jamaluddin, R, Javed, A, Hoa, DTQ, Iida, H, Sim, K, Swe, T, He, YL, Park, Y, Ahmed, HU, De Alwis, A, Chiu, HFK, Sartorius, N, Tan, CH, Chong, MY, Shinfuku, N, Lin, SK, Avasthi, A, Grover, S, Ng, CH, Ungvari, GS & Xiang, YT 2019, 'Prescription of antipsychotic and concomitant medications for adult Asian schizophrenia patients: Findings of the 2016 Research on Asian Psychotropic Prescription Patterns (REAP) survey' Asian Journal of Psychiatry, vol. 45, pp. 74-80. https://doi.org/10.1016/j.ajp.2019.08.010

Prescription of antipsychotic and concomitant medications for adult Asian schizophrenia patients : Findings of the 2016 Research on Asian Psychotropic Prescription Patterns (REAP) survey. / Dong, Min; Zeng, Liang Nan; Zhang, Qinge; Yang, Shu Yu; Chen, Lian Yu; Najoan, Eunice; Kallivayalil, Roy Abraham; Viboonma, Kittisak; Jamaluddin, Ruzita; Javed, Afzal; Hoa, Duong Thi Quynh; Iida, Hitoshi; Sim, Kang; Swe, Thiha; He, Yan Ling; Park, Yongchon; Ahmed, Helal Uddin; De Alwis, Angelo; Chiu, Helen F.K.; Sartorius, Norman; Tan, Chay Hoon; Chong, Mian Yoon; Shinfuku, Naotaka; Lin, Shih Ku; Avasthi, Ajit; Grover, Sandeep; Ng, Chee H.; Ungvari, Gabor S.; Xiang, Yu Tao.

In: Asian Journal of Psychiatry, Vol. 45, 01.10.2019, p. 74-80.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Prescription of antipsychotic and concomitant medications for adult Asian schizophrenia patients

T2 - Findings of the 2016 Research on Asian Psychotropic Prescription Patterns (REAP) survey

AU - Dong, Min

AU - Zeng, Liang Nan

AU - Zhang, Qinge

AU - Yang, Shu Yu

AU - Chen, Lian Yu

AU - Najoan, Eunice

AU - Kallivayalil, Roy Abraham

AU - Viboonma, Kittisak

AU - Jamaluddin, Ruzita

AU - Javed, Afzal

AU - Hoa, Duong Thi Quynh

AU - Iida, Hitoshi

AU - Sim, Kang

AU - Swe, Thiha

AU - He, Yan Ling

AU - Park, Yongchon

AU - Ahmed, Helal Uddin

AU - De Alwis, Angelo

AU - Chiu, Helen F.K.

AU - Sartorius, Norman

AU - Tan, Chay Hoon

AU - Chong, Mian Yoon

AU - Shinfuku, Naotaka

AU - Lin, Shih Ku

AU - Avasthi, Ajit

AU - Grover, Sandeep

AU - Ng, Chee H.

AU - Ungvari, Gabor S.

AU - Xiang, Yu Tao

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Objective: Regular surveys are important to monitor the use of psychotropic medications in clinical practice. This study examined the psychotropic prescription patterns in adult Asian schizophrenia patients based on the data of the Research on Asian Psychotropic Prescription (REAP) 2016 survey. Methods: : This cross-sectional survey across 15 Asian countries/territories collected socio-demographic and clinical data with standardized procedures between March and May 2016. The socio-demographic and clinical characteristics of the patients were recorded with a standardized questionnaire. Results: Altogether 3,537 adult patients with schizophrenia were consecutively screened and enrolled in the survey. The mean age was 38.66 ± 11.55 years and 59.7% of the sample were male. The mean dose of antipsychotics in chlorpromazine equivalents (CPZeq) was 424 ± 376 mg/day; 31.3% and 80.8% received first- and second- generation antipsychotics, respectively and 42.6% had antipsychotic polypharmacy, 11.7% had antidepressants, 13.7% had mood stabilizers, 27.8% had benzodiazepines, and 45.6% had anticholinergics. Conclusions: Psychotropic prescription patterns in Asian adult patients with schizophrenia varied across countries. Regular surveys on psychotropic medications for schizophrenia are important to monitor pharmacotherapy practice in Asia.

AB - Objective: Regular surveys are important to monitor the use of psychotropic medications in clinical practice. This study examined the psychotropic prescription patterns in adult Asian schizophrenia patients based on the data of the Research on Asian Psychotropic Prescription (REAP) 2016 survey. Methods: : This cross-sectional survey across 15 Asian countries/territories collected socio-demographic and clinical data with standardized procedures between March and May 2016. The socio-demographic and clinical characteristics of the patients were recorded with a standardized questionnaire. Results: Altogether 3,537 adult patients with schizophrenia were consecutively screened and enrolled in the survey. The mean age was 38.66 ± 11.55 years and 59.7% of the sample were male. The mean dose of antipsychotics in chlorpromazine equivalents (CPZeq) was 424 ± 376 mg/day; 31.3% and 80.8% received first- and second- generation antipsychotics, respectively and 42.6% had antipsychotic polypharmacy, 11.7% had antidepressants, 13.7% had mood stabilizers, 27.8% had benzodiazepines, and 45.6% had anticholinergics. Conclusions: Psychotropic prescription patterns in Asian adult patients with schizophrenia varied across countries. Regular surveys on psychotropic medications for schizophrenia are important to monitor pharmacotherapy practice in Asia.

KW - Antipsychotics

KW - Asia

KW - Prescription patterns

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=85071968164&partnerID=8YFLogxK

U2 - 10.1016/j.ajp.2019.08.010

DO - 10.1016/j.ajp.2019.08.010

M3 - Review article

VL - 45

SP - 74

EP - 80

JO - Asian Journal of Psychiatry

JF - Asian Journal of Psychiatry

SN - 1876-2018

ER -