Preparation of [64Cu] pyruvaldehyde-bis (N4-methylthiosemicarbazone) complex as a PET and/or therapeutic radiopharmaceutical

A. R. Jalilian, P. Rowshanfarzad, J. Moafian, M. Kamali-dehghan, M. Mirzaii

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Copper-64 (T1/2=12.7 h) is an important radionuclide used both in PET imaging and therapy. [64Cu]-pyruvaldehyde-bis (N4-Methylthiosemicarbazone) ([64Cu]-PTSM) is one of the most famous copper radiopharmaceuticals with unique specifications (suitable half life, stability, etc.). The wide range of 64Cu applications arouse great interest for its production. Materials and methods: Cu-64 was produced via the 68Zn (p,αn) 64Cu nuclear reaction and isolated from the irradiated target by a two-step chemical method. [64Cu]-PTSM was prepared using in-house made PTSM ligand and [64Cu] cuprous acetate. The complex formation parameters (time, temperature, concentration and elution methods) were determined carefully. Results: Copper-64 was prepared in chloride form (≈200 mCi, >95% chemical yield at 180 μA for 1.1 h irradiation, radionuclidic purity >96%, copper-67 as impurity). The solution of 64Cu-PTSM was prepared in >80% radiochemical yield and more than 98% radiochemical purity. Quality controls and stability tests were performed for the final solution. Conclusion: [64Cu]-PTSM was prepared at the radiopharmaceutical scales with high quality and potential to be used in therapeutic/imaging centers.

Original languageEnglish
Pages (from-to)107-115
Number of pages9
JournalIranian Journal of Radiation Research
Volume2
Issue number3
Publication statusPublished - 1 Jan 2004
Externally publishedYes

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