Preparation of [61Cu]DTPA complex as a possible PET tracer

Amir R. Jalilian, Pejman Rowshanfarzad, Mahsheed Sabet, Mohsen Kamalidehghan

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Copper-61 (T1/2 = 3.33 h) produced via the 64Zn(p, α)61Cu nuclear reaction, using a natural zinc target, was separated from the irradiated target material by two ion exchange chromatography steps and was used for the preparation of [61Cu]- diethylenetriaminepentacetate ([61Cu]DTPA) using freshly-prepared DTPA cyclic dianhydride. An electroplated natural zinc layer on a gold-coated copper backing was irradiated with 22 MeV protons (22.12 MeV on the target, 180 μA irradiation, 3.2 h, final activity 220 GBq of 61Cu 2+, RCY > 95%, radionuclidic purity > 99%, 60Cu as the only radionuclidic impurity; T1/2 = 23.7 min). Colorimetric methods showed that traces of chemical impurities in the product were below the accepted limits. The solution of [61Cu]DTPA was prepared with a radiochemical yield of more than 80% starting with 61CuOAc ligand at room temperature after 30 min. RTLC showed the radiochemical purity of more than 99%. The specific activity obtained was about 9.1 TBq/mmol. The tracer was shown to be stable in the final product and in the presence of human serum at 37°C up to 3 h.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
Issue number2
Publication statusPublished - 14 Jun 2006


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