Preparation and quality control of [61Cu]Pyruvaldehyde-Bis (N4-Methylthiosemicarbazone) complex for PET diagnosis

Amir Reza Jalilian, Pejman Rowshan Farzad, Mahseed Sabet, M. Kamalidehgan, Mohammad Mirzaii, Amir A. Rajamand

Research output: Contribution to journalArticlepeer-review


Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) is the most important copper radiopharmaceutical used in clin. expts. In this work. copper-61 (T1/2 = 3.33 h) prodn. process was accomplished via the nat.Zn(p,xn)61Cu, using 22 MeV protons, and the current of 150 $mu$A, resulted in 6.33 Ci of copper-61 with the prodn. yield of 33.3 mCi/$mu$Ah. The complexing agent, PTSM, was synthesized and its structure was confirmed by the common spectroscopic methods. followed by radiolabeling with 61Cu-CuCl2. The final radiopharmaceutical soln. underwent common quality control tests for animal injection.
Original languageEnglish
Pages (from-to)1-8
Number of pages7
JournalJournal of Nuclear Science and Technology
Issue number33
Publication statusPublished - 2005


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