Abstract
Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) is the most important copper radiopharmaceutical used in clin. expts. In this work. copper-61 (T1/2 = 3.33 h) prodn. process was accomplished via the nat.Zn(p,xn)61Cu, using 22 MeV protons, and the current of 150 $mu$A, resulted in 6.33 Ci of copper-61 with the prodn. yield of 33.3 mCi/$mu$Ah. The complexing agent, PTSM, was synthesized and its structure was confirmed by the common spectroscopic methods. followed by radiolabeling with 61Cu-CuCl2. The final radiopharmaceutical soln. underwent common quality control tests for animal injection.
Original language | English |
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Pages (from-to) | 1-8 |
Number of pages | 7 |
Journal | Journal of Nuclear Science and Technology |
Issue number | 33 |
Publication status | Published - 2005 |