Preparation and quality control of [61Cu]Pyruvaldehyde-Bis (N4-Methylthiosemicarbazone) complex for PET diagnosis

Amir Reza Jalilian; Pejman Rowshan Farzad; Mahseed Sabet; M. Kamalidehgan; Mohammad Mirzaii; Amir A. Rajamand

Preparation and quality control of [61Cu]Pyruvaldehyde-Bis (N4-Methylthiosemicarbazone) complex for PET diagnosis

Amir Reza Jalilian, Pejman Rowshan Farzad, Mahseed Sabet, M. Kamalidehgan, Mohammad Mirzaii, Amir A. Rajamand

School of Physics, Mathematics and Computing

Research output: Contribution to journal › Article › peer-review

Abstract

Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) is the most important copper radiopharmaceutical used in clin. expts. In this work. copper-61 (T1/2 = 3.33 h) prodn. process was accomplished via the nat.Zn(p,xn)61Cu, using 22 MeV protons, and the current of 150 $mu$A, resulted in 6.33 Ci of copper-61 with the prodn. yield of 33.3 mCi/$mu$Ah. The complexing agent, PTSM, was synthesized and its structure was confirmed by the common spectroscopic methods. followed by radiolabeling with 61Cu-CuCl2. The final radiopharmaceutical soln. underwent common quality control tests for animal injection.

Original language	English
Pages (from-to)	1-8
Number of pages	7
Journal	Journal of Nuclear Science and Technology
Issue number	33
Publication status	Published - 2005

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title = "Preparation and quality control of [61Cu]Pyruvaldehyde-Bis (N4-Methylthiosemicarbazone) complex for PET diagnosis",

abstract = "Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) is the most important copper radiopharmaceutical used in clin. expts. In this work. copper-61 (T1/2 = 3.33 h) prodn. process was accomplished via the nat.Zn(p,xn)61Cu, using 22 MeV protons, and the current of 150 $mu$A, resulted in 6.33 Ci of copper-61 with the prodn. yield of 33.3 mCi/$mu$Ah. The complexing agent, PTSM, was synthesized and its structure was confirmed by the common spectroscopic methods. followed by radiolabeling with 61Cu-CuCl2. The final radiopharmaceutical soln. underwent common quality control tests for animal injection. ",

author = "Jalilian, {Amir Reza} and {Rowshan Farzad}, Pejman and Mahseed Sabet and M. Kamalidehgan and Mohammad Mirzaii and Rajamand, {Amir A.}",

year = "2005",

language = "English",

pages = "1--8",

journal = "Journal of Nuclear Science and Technology",

issn = "1735-1871",

publisher = "Atomic Energy Organization of Iran",

number = "33",

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TY - JOUR

T1 - Preparation and quality control of [61Cu]Pyruvaldehyde-Bis (N4-Methylthiosemicarbazone) complex for PET diagnosis

AU - Jalilian, Amir Reza

AU - Rowshan Farzad, Pejman

AU - Sabet, Mahseed

AU - Kamalidehgan, M.

AU - Mirzaii, Mohammad

AU - Rajamand, Amir A.

PY - 2005

Y1 - 2005

N2 - Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) is the most important copper radiopharmaceutical used in clin. expts. In this work. copper-61 (T1/2 = 3.33 h) prodn. process was accomplished via the nat.Zn(p,xn)61Cu, using 22 MeV protons, and the current of 150 $mu$A, resulted in 6.33 Ci of copper-61 with the prodn. yield of 33.3 mCi/$mu$Ah. The complexing agent, PTSM, was synthesized and its structure was confirmed by the common spectroscopic methods. followed by radiolabeling with 61Cu-CuCl2. The final radiopharmaceutical soln. underwent common quality control tests for animal injection.

AB - Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) is the most important copper radiopharmaceutical used in clin. expts. In this work. copper-61 (T1/2 = 3.33 h) prodn. process was accomplished via the nat.Zn(p,xn)61Cu, using 22 MeV protons, and the current of 150 $mu$A, resulted in 6.33 Ci of copper-61 with the prodn. yield of 33.3 mCi/$mu$Ah. The complexing agent, PTSM, was synthesized and its structure was confirmed by the common spectroscopic methods. followed by radiolabeling with 61Cu-CuCl2. The final radiopharmaceutical soln. underwent common quality control tests for animal injection.

M3 - Article

SP - 1

EP - 8

JO - Journal of Nuclear Science and Technology

JF - Journal of Nuclear Science and Technology

SN - 1735-1871

IS - 33

ER -

Preparation and quality control of [61Cu]Pyruvaldehyde-Bis (N4-Methylthiosemicarbazone) complex for PET diagnosis

Abstract

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