Pregnancy in women with mitochondrial disease—A literature review and suggested guidance for preconception and pregnancy care

Lisa Hui, Pema Hayman, Ali Buckland, Michael C. Fahey, David A. Mackey, Andrew J. Mallett, Daniel R. Schweitzer, Clare P. Stuart, Wai Yan Yau, John Christodoulou

Research output: Contribution to journalReview articlepeer-review

Abstract

Mitochondrial donation to reduce the risk of primary mitochondrial disease transmission from mother to child is now permitted under Australian law as part of a clinical trial. The energy demands of pregnancy have the potential to worsen mitochondrial disease symptoms and severity in affected women. We conducted a systematic literature review on mitochondrial disease in pregnancy; five cohort studies and 19 case reports were included. For many women with mitochondrial disease, pregnancy does not have a negative effect on health status. However, serious adverse outcomes may occur. We provide suggested guidelines for preconception counselling and antenatal care.

Original languageEnglish
Number of pages7
JournalAustralian and New Zealand Journal of Obstetrics and Gynaecology
DOIs
Publication statusE-pub ahead of print - 11 Sept 2024

Fingerprint

Dive into the research topics of 'Pregnancy in women with mitochondrial disease—A literature review and suggested guidance for preconception and pregnancy care'. Together they form a unique fingerprint.

Cite this