Pregnancy after breast cancer: Are young patients willing to participate in clinical studies?

O. Pagani, M. Ruggeri, S. Manunta, Christobel Saunders, F. Peccatori, F. Cardoso, B. Kaufman, S. Paluch-Shimon, H. Gewefel, E. Gallerani, O. Abulkhair, B. Pistilli, E. Warner, E. Saloustros, L. Perey, K. Zaman, M. Rabaglio, S. Gelber, R.D. Gelber, A. GoldhirschL. Korde, H.A. Azim, A.H. Partridge

    Research output: Contribution to journalArticlepeer-review

    86 Citations (Scopus)


    © 2015 Elsevier Ltd. Young patients with breast cancer (BC) are often concerned about treatment-induced infertility and express maternity desire. Conception after BC does not seem to affect outcome, but information in estrogen-receptor positive (ER+) disease is not definitive. From September 2012-March 2013, 212 evaluable patients with ER+ early BC, 30 months was higher (83%) than in older women (14%), interest was independent of age in patients treated for ≤30 months. A prospective study in this patient population seems relevant and feasible. The International-Breast-Cancer-Study-Group (IBCSG), within the Breast-International-Group (BIG) - North-American-Breast-Cancer-Groups (NABCG) collaboration, is launching a study (POSITIVE) addressing ET interruption to allow pregnancy.
    Original languageEnglish
    Pages (from-to)201-207
    Issue number3
    Publication statusPublished - 2015


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