Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes

T. Kaartokallio, A.I. Lokki, H. Peterson, K. Kivinen, L. Hiltunen, E. Salmela, T. Lappalainen, P. Maanselkä, S. Heino, S. Knuutila, A. Sayed, L. Poston, S.P. Brennecke, M.P. Johnson, L. Morgan, Eric Moses, J. Kere, H. Laivuori

Research output: Contribution to journalArticle

Abstract

© 2016 Informa UK Limited, trading as Taylor & Francis Group.Introduction: Preeclampsia is a common and partially genetic pregnancy complication characterized by hypertension and proteinuria. Association with cardiovascular disease and type 2 diabetes has been reported in 9p21 by several genome-wide association studies. It has been hypothesized that cardiometabolic diseases may share common etiology with preeclampsia. Materials and methods: We tested association with the 9p21 region to preeclampsia in the Finnish population by genotyping 23 tagging single nucleotide polymorphisms (SNPs) in 15 extended preeclampsia families and in a nationwide cohort consisting of 281 cases and 349 matched controls. Replication was conducted in additional datasets. Results: Four SNPs (rs7044859, rs496892, rs564398 and rs7865618) showed nominal association (p = 0.024 uncorrected) with preeclampsia in the case-control cohort. To increase power, we genotyped two SNPs in additional 388 cases and 341 controls from the Finnish Genetics of Preeclampsia Consortium (FINNPEC) cohort. Partial replication was also attempted in a UK cohort (237 cases and 199 controls) and in 74 preeclamptic families from Australia/New Zealand. We were unable to replicate the initial association in the extended Finnish dataset or in the two international cohorts. Conclusions: Our study did not find evidence for the involvement of the 9p21 region in the risk of preeclampsia. Key Message Chromosome 9p21 is not associated with preeclampsia.
Original languageEnglish
Pages (from-to)330-336
Number of pages7
JournalAnnals of Medicine
Volume48
Issue number5
DOIs
Publication statusPublished - 25 Apr 2016

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Pre-Eclampsia
Type 2 Diabetes Mellitus
Coronary Artery Disease
Alleles
Single Nucleotide Polymorphism
Pregnancy Complications
Genome-Wide Association Study
New Zealand
Proteinuria
Cardiovascular Diseases
Chromosomes
Hypertension
Population

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Kaartokallio, T., Lokki, A. I., Peterson, H., Kivinen, K., Hiltunen, L., Salmela, E., ... Laivuori, H. (2016). Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes. Annals of Medicine, 48(5), 330-336. https://doi.org/10.1080/07853890.2016.1174877
Kaartokallio, T. ; Lokki, A.I. ; Peterson, H. ; Kivinen, K. ; Hiltunen, L. ; Salmela, E. ; Lappalainen, T. ; Maanselkä, P. ; Heino, S. ; Knuutila, S. ; Sayed, A. ; Poston, L. ; Brennecke, S.P. ; Johnson, M.P. ; Morgan, L. ; Moses, Eric ; Kere, J. ; Laivuori, H. / Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes. In: Annals of Medicine. 2016 ; Vol. 48, No. 5. pp. 330-336.
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Kaartokallio, T, Lokki, AI, Peterson, H, Kivinen, K, Hiltunen, L, Salmela, E, Lappalainen, T, Maanselkä, P, Heino, S, Knuutila, S, Sayed, A, Poston, L, Brennecke, SP, Johnson, MP, Morgan, L, Moses, E, Kere, J & Laivuori, H 2016, 'Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes' Annals of Medicine, vol. 48, no. 5, pp. 330-336. https://doi.org/10.1080/07853890.2016.1174877

Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes. / Kaartokallio, T.; Lokki, A.I.; Peterson, H.; Kivinen, K.; Hiltunen, L.; Salmela, E.; Lappalainen, T.; Maanselkä, P.; Heino, S.; Knuutila, S.; Sayed, A.; Poston, L.; Brennecke, S.P.; Johnson, M.P.; Morgan, L.; Moses, Eric; Kere, J.; Laivuori, H.

In: Annals of Medicine, Vol. 48, No. 5, 25.04.2016, p. 330-336.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes

AU - Kaartokallio, T.

AU - Lokki, A.I.

AU - Peterson, H.

AU - Kivinen, K.

AU - Hiltunen, L.

AU - Salmela, E.

AU - Lappalainen, T.

AU - Maanselkä, P.

AU - Heino, S.

AU - Knuutila, S.

AU - Sayed, A.

AU - Poston, L.

AU - Brennecke, S.P.

AU - Johnson, M.P.

AU - Morgan, L.

AU - Moses, Eric

AU - Kere, J.

AU - Laivuori, H.

PY - 2016/4/25

Y1 - 2016/4/25

N2 - © 2016 Informa UK Limited, trading as Taylor & Francis Group.Introduction: Preeclampsia is a common and partially genetic pregnancy complication characterized by hypertension and proteinuria. Association with cardiovascular disease and type 2 diabetes has been reported in 9p21 by several genome-wide association studies. It has been hypothesized that cardiometabolic diseases may share common etiology with preeclampsia. Materials and methods: We tested association with the 9p21 region to preeclampsia in the Finnish population by genotyping 23 tagging single nucleotide polymorphisms (SNPs) in 15 extended preeclampsia families and in a nationwide cohort consisting of 281 cases and 349 matched controls. Replication was conducted in additional datasets. Results: Four SNPs (rs7044859, rs496892, rs564398 and rs7865618) showed nominal association (p = 0.024 uncorrected) with preeclampsia in the case-control cohort. To increase power, we genotyped two SNPs in additional 388 cases and 341 controls from the Finnish Genetics of Preeclampsia Consortium (FINNPEC) cohort. Partial replication was also attempted in a UK cohort (237 cases and 199 controls) and in 74 preeclamptic families from Australia/New Zealand. We were unable to replicate the initial association in the extended Finnish dataset or in the two international cohorts. Conclusions: Our study did not find evidence for the involvement of the 9p21 region in the risk of preeclampsia. Key Message Chromosome 9p21 is not associated with preeclampsia.

AB - © 2016 Informa UK Limited, trading as Taylor & Francis Group.Introduction: Preeclampsia is a common and partially genetic pregnancy complication characterized by hypertension and proteinuria. Association with cardiovascular disease and type 2 diabetes has been reported in 9p21 by several genome-wide association studies. It has been hypothesized that cardiometabolic diseases may share common etiology with preeclampsia. Materials and methods: We tested association with the 9p21 region to preeclampsia in the Finnish population by genotyping 23 tagging single nucleotide polymorphisms (SNPs) in 15 extended preeclampsia families and in a nationwide cohort consisting of 281 cases and 349 matched controls. Replication was conducted in additional datasets. Results: Four SNPs (rs7044859, rs496892, rs564398 and rs7865618) showed nominal association (p = 0.024 uncorrected) with preeclampsia in the case-control cohort. To increase power, we genotyped two SNPs in additional 388 cases and 341 controls from the Finnish Genetics of Preeclampsia Consortium (FINNPEC) cohort. Partial replication was also attempted in a UK cohort (237 cases and 199 controls) and in 74 preeclamptic families from Australia/New Zealand. We were unable to replicate the initial association in the extended Finnish dataset or in the two international cohorts. Conclusions: Our study did not find evidence for the involvement of the 9p21 region in the risk of preeclampsia. Key Message Chromosome 9p21 is not associated with preeclampsia.

U2 - 10.1080/07853890.2016.1174877

DO - 10.1080/07853890.2016.1174877

M3 - Article

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EP - 336

JO - Annals of Medicine

JF - Annals of Medicine

SN - 0785-3890

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ER -