Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts

A.M. Martin, D. Nolan, I. James, P. Cameron, J. Keller, C. Moore, E. Phillips, Frank Christiansen, S. Mallal

    Research output: Contribution to journalArticle

    268 Citations (Scopus)

    Abstract

    Genetic (human leukocyte antigen), disease-related and demographic risk factors for nevirapine reactions were examined in a nevirapine-exposed cohort. Cases involving combinations of hepatitis, fever or rash were associated with an interaction between HLA-DRB1*0101 and the percentage of CD4, whereas no associations were detected for isolated rash. These data suggest that HLA-DRB1*0101 and the CD4 status may determine susceptibility to nevirapine hypersensitivity, consistent with a CD4 T-cell-dependent immune response to nevirapine-specific antigens.
    Original languageEnglish
    Pages (from-to)97-99
    Number of pages3
    JournalAIDS
    Volume19
    Issue number1
    DOIs
    Publication statusPublished - 2005

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