Prediction of malignant transformation and recurrence of oral epithelial dysplasia using architectural and cytological feature specific prognostic models

Hanya Mahmood, M. Bradburn, Nasir Rajpoot, Nadim Mohammed Islam, Omar Kujan, Syed Ali Khurram

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)
70 Downloads (Pure)

Abstract

Oral epithelial dysplasia (OED) is a precursor state usually preceding oral squamous cell carcinoma (OSCC). Histological grading is the current gold standard for OED prognostication but is subjective and variable with unreliable outcome prediction. We explore if individual OED histological features can be used to develop and evaluate prognostic models for malignant transformation and recurrence prediction. Digitised tissue slides for a cohort of 109 OED cases were reviewed by three expert pathologists, where the prevalence and agreement of architectural and cytological histological features was assessed and association with clinical outcomes analysed using Cox proportional hazards regression and Kaplan–Meier curves. Within the cohort, the most prevalent features were basal cell hyperplasia (72%) and irregular surface keratin (60%), and least common were verrucous surface (26%), loss of epithelial cohesion (30%), lymphocytic band and dyskeratosis (34%). Several features were significant for transformation (p 
Original languageEnglish
Pages (from-to)1151-1159
Number of pages9
JournalModern Pathology
Volume35
Issue number9
Early online date31 Mar 2022
DOIs
Publication statusPublished - Sept 2022

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