Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus

Mahvash Sadeghi; Sajad Dehnavi; Mojtaba Shohan; Tannaz Jamialahmadi; Thozhukat Sathyapalan; Amirhossein Sahebkar

doi:10.2174/0929867329666220817142848

Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus

Mahvash Sadeghi, Sajad Dehnavi, Mojtaba Shohan, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar

UWA Medical School

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and associated with multiple organ systems complications. The incidence and prevalence of diabetes are increasing in an epidemic proportion worldwide. In addition to environmental factors, some epigenetic and post-translational modifications have critical roles in the pathogenesis of diabetes and its complications. Reversible covalent modification such as SUMOylation by SUMO (Small Ubiquitin-like Modifier) has emerged as a new mechanism that affects the dynamic regulation of proteins. In this review, we initially focus on the function of SUMO and SUMOylation. Subsequently, we assess the potential effects of this process in the pathogenesis of type 1 and 2 diabetes mellitus.

Original language	English
Pages (from-to)	1623-1637
Number of pages	15
Journal	Current Medicinal Chemistry
Volume	30
Issue number	14
DOIs	https://doi.org/10.2174/0929867329666220817142848
Publication status	Published - 1 Apr 2023

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abstract = "Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and associated with multiple organ systems complications. The incidence and prevalence of diabetes are increasing in an epidemic proportion worldwide. In addition to environmental factors, some epigenetic and post-translational modifications have critical roles in the pathogenesis of diabetes and its complications. Reversible covalent modification such as SUMOylation by SUMO (Small Ubiquitin-like Modifier) has emerged as a new mechanism that affects the dynamic regulation of proteins. In this review, we initially focus on the function of SUMO and SUMOylation. Subsequently, we assess the potential effects of this process in the pathogenesis of type 1 and 2 diabetes mellitus.",

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AU - Shohan, Mojtaba

AU - Jamialahmadi, Tannaz

AU - Sathyapalan, Thozhukat

AU - Sahebkar, Amirhossein

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Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus

Abstract

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