Projects per year
Abstract
There is currently no effective treatment for dementia, of which Alzheimer's disease (AD) is the most common form. It is, therefore, imperative to focus on evidence-based preventive strategies to combat this extremely debilitating chronic disease. Nitric oxide (NO) is a key signalling molecule in the cardiovascular, cerebrovascular, and central nervous systems. Vegetables rich in nitrate, such as spinach and beetroot, are an important source of NO, with beneficial effects on validated markers of cardiovascular health and an association with a lower risk of cardiovascular disease. Given the link between cardiovascular disease risk factors and dementia, together with the important role of NO in vascular health and cognition, it is important to determine whether dietary nitrate could also improve cognitive function, markers of brain health, and lower risk of dementia. This review presents an overview of NO's role in the cardiovascular, cerebrovascular, and central nervous systems; an overview of the available evidence that nitrate, through effects on NO, improves cardiovascular health; and evaluates the current evidence regarding dietary nitrate's potential role in cerebrovascular health, cognitive function, and brain health assessed via biomarkers.
Original language | English |
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Pages (from-to) | 12572-12589 |
Number of pages | 18 |
Journal | Food & function |
Volume | 13 |
Issue number | 24 |
Early online date | 9 Nov 2022 |
DOIs | |
Publication status | Published - 9 Nov 2022 |
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Dive into the research topics of 'Potential role of dietary nitrate in relation to cardiovascular and cerebrovascular health, cognition, cognitive decline and dementia: a review'. Together they form a unique fingerprint.Projects
- 2 Curtailed
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Variations in flavonoid metabolism as an explanation for inter-individual differences in physiological responses to flavonoid-rich foods
Bondonno, N. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/19 → 9/10/20
Project: Research
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Dietary approaches to enhance vascular health
Hodgson, J. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/17 → 9/10/20
Project: Research