Potential novel anxiolytic drugs

D. Christmas, Sean Hood, D. Nutt

    Research output: Contribution to journalArticlepeer-review

    38 Citations (Scopus)

    Abstract

    Anxiety disorders are common and disabling conditions. Current drug treatment methods have limitations including resistance, delayed efficacy and side effects. The advent of sophisticated imaging techniques and the production of highly selective receptor ligands have increased our knowledge of the biological mechanisms underpinning anxiety. Our aim is to review recent discoveries in important neurological systems to provide an understanding of important current anxiolytic targets. Some of these systems, such as GABA, have been implicated in anxiety disorders for decades, but a recent greater understanding is enabling more sophisticated targeting of treatments. In other systems, including the neuropeptides, we have now developed the pharmacological tools in human subjects to begin exploring their relationship to anxiety disorders. We review GABA, serotonin, glutamate, noradrenaline, dopamine and some neuropeptides herein.
    Original languageEnglish
    Pages (from-to)3534-3546
    JournalCurrent Pharmaceutical Design
    Volume14
    Issue number33
    DOIs
    Publication statusPublished - 2008

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