Potential for interferon-a-based therapy in mesothelioma: assessment in a murine model

H. Bielefeldt-Ohmann, D.R. Fitzpatrick, A.L. Marzo, A.G. Jarnicki, A.W. Musk, Bruce Robinson

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Malignant mesothelioma is an aggressive tumor, usually induced by asbestos exposure, that has a poor prognosis and is unresponsive to conventional therapy. The present study was aimed at assessing the potential for interferon-alpha (IFN-alpha)-based therapies in a murine model for malignant mesothelioma. The effect of recombinant human IFN-alpha B/D on tumor growth, alone and in combination with either of two immunamodulatory and antiproliferative agents beta-carotene or alpha-difluoromethylornithine (DFMO), was assessed. The data suggest that IFN-alpha treatment is most efficacious when commenced early in tumor development. Combination of IFN-alpha with either DFMO or dietary beta-carotene supplementation improved the effect of an otherwise suboptimal IFN-alpha therapy regimen. Both IFN-alpha and beta-carotene had in vivo stimulatory effects on immune cells, perhaps indirectly by inhibiting TGF-beta generation. The immunomodulatory effects may contribute, at least in part, to the positive antitumor and clinical activities of the treatments in this model.
Original languageEnglish
Pages (from-to)213-223
JournalJournal of Interferon and Cytokine Research
Volume15
DOIs
Publication statusPublished - 1995

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