TY - JOUR
T1 - Potential anti-inflammatory and anti-cancer properties of farnesol
AU - Jung, Young Yun
AU - Hwang, Sun Tae
AU - Sethi, Gautam
AU - Fan, Lu
AU - Arfuso, Frank
AU - Ahn, Kwang Seok
N1 - Funding Information:
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) [NRF-2017M3A9E4065333, and 2018R1D1A1B07042969] to KSA.
Funding Information:
Funding: This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) [NRF-2017M3A9E4065333, and 2018R1D1A1B07042969] to KSA.
Publisher Copyright:
© 2018 by the authors.
PY - 2018/10/31
Y1 - 2018/10/31
N2 - Farnesol, an acyclic sesquiterpene alcohol, is predominantly found in essential oils of various plants in nature. It has been reported to exhibit anti-cancer and anti-inflammatory effects, and also alleviate allergic asthma, gliosis, and edema. In numerous tumor cell lines, farnesol can modulate various tumorigenic proteins and/or modulates diverse signal transduction cascades. It can also induce apoptosis and downregulate cell proliferation, angiogenesis, and cell survival. To exert its anti-inflammatory/anti-oncogenic effects, farnesol can modulate Ras protein and nuclear factor kappa-light-chain-enhancer of activated B cells activation to downregulate the expression of various inflammatory mediators such as cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor alpha, and interleukin-6. In this review, we describe the potential mechanisms of action underlying the therapeutic effects of farnesol against cancers and inflammatory disorders. Furthermore, these findings support the clinical development of farnesol as a potential pharmacological agent in clinical studies.
AB - Farnesol, an acyclic sesquiterpene alcohol, is predominantly found in essential oils of various plants in nature. It has been reported to exhibit anti-cancer and anti-inflammatory effects, and also alleviate allergic asthma, gliosis, and edema. In numerous tumor cell lines, farnesol can modulate various tumorigenic proteins and/or modulates diverse signal transduction cascades. It can also induce apoptosis and downregulate cell proliferation, angiogenesis, and cell survival. To exert its anti-inflammatory/anti-oncogenic effects, farnesol can modulate Ras protein and nuclear factor kappa-light-chain-enhancer of activated B cells activation to downregulate the expression of various inflammatory mediators such as cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor alpha, and interleukin-6. In this review, we describe the potential mechanisms of action underlying the therapeutic effects of farnesol against cancers and inflammatory disorders. Furthermore, these findings support the clinical development of farnesol as a potential pharmacological agent in clinical studies.
KW - Apoptosis
KW - Cancer
KW - Farnesol
KW - Inflammation
UR - http://www.scopus.com/inward/record.url?scp=85055907380&partnerID=8YFLogxK
U2 - 10.3390/molecules23112827
DO - 10.3390/molecules23112827
M3 - Review article
C2 - 30384444
AN - SCOPUS:85055907380
SN - 1420-3049
VL - 23
JO - Molecules
JF - Molecules
IS - 11
M1 - 2827
ER -
