TY - JOUR
T1 - Postprandial Hypertriglyceridaemia Revisited in the Era of Non-Fasting Lipid Profile Testing
T2 - A 2019 Expert Panel Statement, Narrative Review
AU - Kolovou, Genovefa D.
AU - Watts, Gerald F.
AU - Mikhailidis, Dimitri P.
AU - Pérez-Martínez, Pablo
AU - Mora, Samia
AU - Bilianou, Helen
AU - Panotopoulos, George
AU - Katsiki, Niki
AU - Ooi, Teik C.
AU - Lopez-Miranda, José
AU - Tybjærg-Hansen, Anne
AU - Tentolouris, Nicholas
AU - Nordestgaard, Børge G.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Postprandial hypertriglyceridaemia, defined as an increase in plasma triglyceride-containing lipoproteins following a fat meal, is a potential risk predictor of atherosclerotic cardiovascular disease and other chronic diseases. Several non-modifiable factors (genetics, age, sex and menopausal status) and lifestyle factors (diet, physical activity, smoking status, obesity, alcohol and medication use) may influence postprandial hypertriglyceridaemia. This narrative review considers the studies published over the last decade that evaluated postprandial hypertriglyceridaemia. Additionally, the genetic determinants of postprandial plasma triglyceride levels, the types of meals for studying postprandial triglyceride response, and underlying conditions (e.g. familial dyslipidaemias, diabetes mellitus, metabolic syndrome, non-alcoholic fatty liver and chronic kidney disease) that are associated with postprandial hypertriglyceridaemia are reviewed; therapeutic aspects are also considered.
AB - Postprandial hypertriglyceridaemia, defined as an increase in plasma triglyceride-containing lipoproteins following a fat meal, is a potential risk predictor of atherosclerotic cardiovascular disease and other chronic diseases. Several non-modifiable factors (genetics, age, sex and menopausal status) and lifestyle factors (diet, physical activity, smoking status, obesity, alcohol and medication use) may influence postprandial hypertriglyceridaemia. This narrative review considers the studies published over the last decade that evaluated postprandial hypertriglyceridaemia. Additionally, the genetic determinants of postprandial plasma triglyceride levels, the types of meals for studying postprandial triglyceride response, and underlying conditions (e.g. familial dyslipidaemias, diabetes mellitus, metabolic syndrome, non-alcoholic fatty liver and chronic kidney disease) that are associated with postprandial hypertriglyceridaemia are reviewed; therapeutic aspects are also considered.
KW - anti-obesity drugs
KW - atherosclerotic cardiovascular disease
KW - bariatric surgery
KW - chronic kidney disease
KW - diabetes mellitus
KW - ezetimibe
KW - familial dyslipidaemia
KW - fibrates
KW - lipoprotein apheresis
KW - metabolic syndrome
KW - n-3 fatty acids
KW - nicotinic acid
KW - non-alcoholic fatty liver
KW - oral fat tolerance test
KW - PCSK9 inhibitors
KW - Postprandial hypertriglyceridaemia
KW - statins
KW - triglycerides.
UR - http://www.scopus.com/inward/record.url?scp=85071782649&partnerID=8YFLogxK
U2 - 10.2174/1570161117666190503123911
DO - 10.2174/1570161117666190503123911
M3 - Article
C2 - 31309820
AN - SCOPUS:85071782649
SN - 1570-1611
VL - 17
SP - 515
EP - 537
JO - Current Vascular Pharmacology
JF - Current Vascular Pharmacology
IS - 5
ER -