Postoperative analgesic efficacy of dexamethasone sodium phosphate versus triamcinolone acetonide in bunionectomy: A prospective, single-blinded pilot randomized controlled trial

Chris Olivia Ongzalima, Wei Lin Renee Lee, Anh Hoang, Ming Yi Wong, Reza Nezami Naraghi

Research output: Contribution to journalArticle

Abstract

Background: Corticosteroids are often administered via injection preoperatively to reduce post-operative inflammation and pain. Despite their wide anecdotal application in clinical practice, there are no current guidelines pertaining to appropriate corticosteroid selection. This study aims to investigate and compare the efficacy of dexamethasone sodium phosphate (DSP) and triamcinolone acetonide (TA) in postoperative pain management following hallux valgus surgery. Methods: A randomized, prospective, single-blind study comparing preoperative DSP versus TA injections was conducted on 20 participants who were undergoing elective hallux valgus surgery. Postoperative pain scores (pain intensity and pain interference with daily activities) were assessed with Brief Pain Inventory Short Form (BPI-sf) questionnaire at the time of first postoperative oral analgesic consumption or 14 days after surgery if no analgesics were required. Differences in clinically significant pain scores were also assessed with prospectively defined response criteria. Results: The difference in mean for pain intensity and pain interference were found to be significantly lower for TA group as compared to DSP group (p = 0.006 and p = 0.001) respectively. Significant difference was also observed in the proportion of participants who reported absence of postoperative pain scores between DSP and TA groups (p = 0.025 and p= 0.006) respectively. However, there were no significant differences between time to postoperative analgesia consumption and proportion of participants requiring oral analgesia (p>0.05). Conclusions: This study provides preliminary evidence suggesting that TA is associated with lower pain scores compared to DSP. Further research is required to establish the effects of TA and DSP in managing postoperative pain following hallux valgus surgery. Key words: Hallux valgus; Bunionectomy; Corticosteroid; Triamcinolone Acetonide; Dexamethasone Sodium Phosphate; Podiatry; Post-operative; Pain; Analgesics
Original languageEnglish
Number of pages9
JournalThe Foot and Ankle Online Journal
Volume9
Issue number2
DOIs
Publication statusPublished - 30 Jun 2016

Fingerprint

dexamethasone 21-phosphate
Triamcinolone Acetonide
Analgesics
Randomized Controlled Trials
Pain
Hallux Valgus
Postoperative Pain
Adrenal Cortex Hormones
Analgesia
Podiatry
Single-Blind Method
Injections

Cite this

@article{ece27c9bdd2f46098e13db2d057f507a,
title = "Postoperative analgesic efficacy of dexamethasone sodium phosphate versus triamcinolone acetonide in bunionectomy: A prospective, single-blinded pilot randomized controlled trial",
abstract = "Background: Corticosteroids are often administered via injection preoperatively to reduce post-operative inflammation and pain. Despite their wide anecdotal application in clinical practice, there are no current guidelines pertaining to appropriate corticosteroid selection. This study aims to investigate and compare the efficacy of dexamethasone sodium phosphate (DSP) and triamcinolone acetonide (TA) in postoperative pain management following hallux valgus surgery. Methods: A randomized, prospective, single-blind study comparing preoperative DSP versus TA injections was conducted on 20 participants who were undergoing elective hallux valgus surgery. Postoperative pain scores (pain intensity and pain interference with daily activities) were assessed with Brief Pain Inventory Short Form (BPI-sf) questionnaire at the time of first postoperative oral analgesic consumption or 14 days after surgery if no analgesics were required. Differences in clinically significant pain scores were also assessed with prospectively defined response criteria. Results: The difference in mean for pain intensity and pain interference were found to be significantly lower for TA group as compared to DSP group (p = 0.006 and p = 0.001) respectively. Significant difference was also observed in the proportion of participants who reported absence of postoperative pain scores between DSP and TA groups (p = 0.025 and p= 0.006) respectively. However, there were no significant differences between time to postoperative analgesia consumption and proportion of participants requiring oral analgesia (p>0.05). Conclusions: This study provides preliminary evidence suggesting that TA is associated with lower pain scores compared to DSP. Further research is required to establish the effects of TA and DSP in managing postoperative pain following hallux valgus surgery. Key words: Hallux valgus; Bunionectomy; Corticosteroid; Triamcinolone Acetonide; Dexamethasone Sodium Phosphate; Podiatry; Post-operative; Pain; Analgesics",
author = "Ongzalima, {Chris Olivia} and Lee, {Wei Lin Renee} and Anh Hoang and Wong, {Ming Yi} and Naraghi, {Reza Nezami}",
year = "2016",
month = "6",
day = "30",
doi = "10.3827/faoj.2016.0902.0003",
language = "English",
volume = "9",
journal = "The Foot and Ankle Online Journal",
issn = "1941-6806",
number = "2",

}

Postoperative analgesic efficacy of dexamethasone sodium phosphate versus triamcinolone acetonide in bunionectomy: A prospective, single-blinded pilot randomized controlled trial. / Ongzalima, Chris Olivia ; Lee, Wei Lin Renee ; Hoang, Anh; Wong, Ming Yi ; Naraghi, Reza Nezami.

In: The Foot and Ankle Online Journal, Vol. 9, No. 2, 30.06.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Postoperative analgesic efficacy of dexamethasone sodium phosphate versus triamcinolone acetonide in bunionectomy: A prospective, single-blinded pilot randomized controlled trial

AU - Ongzalima, Chris Olivia

AU - Lee, Wei Lin Renee

AU - Hoang, Anh

AU - Wong, Ming Yi

AU - Naraghi, Reza Nezami

PY - 2016/6/30

Y1 - 2016/6/30

N2 - Background: Corticosteroids are often administered via injection preoperatively to reduce post-operative inflammation and pain. Despite their wide anecdotal application in clinical practice, there are no current guidelines pertaining to appropriate corticosteroid selection. This study aims to investigate and compare the efficacy of dexamethasone sodium phosphate (DSP) and triamcinolone acetonide (TA) in postoperative pain management following hallux valgus surgery. Methods: A randomized, prospective, single-blind study comparing preoperative DSP versus TA injections was conducted on 20 participants who were undergoing elective hallux valgus surgery. Postoperative pain scores (pain intensity and pain interference with daily activities) were assessed with Brief Pain Inventory Short Form (BPI-sf) questionnaire at the time of first postoperative oral analgesic consumption or 14 days after surgery if no analgesics were required. Differences in clinically significant pain scores were also assessed with prospectively defined response criteria. Results: The difference in mean for pain intensity and pain interference were found to be significantly lower for TA group as compared to DSP group (p = 0.006 and p = 0.001) respectively. Significant difference was also observed in the proportion of participants who reported absence of postoperative pain scores between DSP and TA groups (p = 0.025 and p= 0.006) respectively. However, there were no significant differences between time to postoperative analgesia consumption and proportion of participants requiring oral analgesia (p>0.05). Conclusions: This study provides preliminary evidence suggesting that TA is associated with lower pain scores compared to DSP. Further research is required to establish the effects of TA and DSP in managing postoperative pain following hallux valgus surgery. Key words: Hallux valgus; Bunionectomy; Corticosteroid; Triamcinolone Acetonide; Dexamethasone Sodium Phosphate; Podiatry; Post-operative; Pain; Analgesics

AB - Background: Corticosteroids are often administered via injection preoperatively to reduce post-operative inflammation and pain. Despite their wide anecdotal application in clinical practice, there are no current guidelines pertaining to appropriate corticosteroid selection. This study aims to investigate and compare the efficacy of dexamethasone sodium phosphate (DSP) and triamcinolone acetonide (TA) in postoperative pain management following hallux valgus surgery. Methods: A randomized, prospective, single-blind study comparing preoperative DSP versus TA injections was conducted on 20 participants who were undergoing elective hallux valgus surgery. Postoperative pain scores (pain intensity and pain interference with daily activities) were assessed with Brief Pain Inventory Short Form (BPI-sf) questionnaire at the time of first postoperative oral analgesic consumption or 14 days after surgery if no analgesics were required. Differences in clinically significant pain scores were also assessed with prospectively defined response criteria. Results: The difference in mean for pain intensity and pain interference were found to be significantly lower for TA group as compared to DSP group (p = 0.006 and p = 0.001) respectively. Significant difference was also observed in the proportion of participants who reported absence of postoperative pain scores between DSP and TA groups (p = 0.025 and p= 0.006) respectively. However, there were no significant differences between time to postoperative analgesia consumption and proportion of participants requiring oral analgesia (p>0.05). Conclusions: This study provides preliminary evidence suggesting that TA is associated with lower pain scores compared to DSP. Further research is required to establish the effects of TA and DSP in managing postoperative pain following hallux valgus surgery. Key words: Hallux valgus; Bunionectomy; Corticosteroid; Triamcinolone Acetonide; Dexamethasone Sodium Phosphate; Podiatry; Post-operative; Pain; Analgesics

U2 - 10.3827/faoj.2016.0902.0003

DO - 10.3827/faoj.2016.0902.0003

M3 - Article

VL - 9

JO - The Foot and Ankle Online Journal

JF - The Foot and Ankle Online Journal

SN - 1941-6806

IS - 2

ER -