Posterior reversible encephalopathy syndrome (PRES): diagnosis and management

James D. Triplett, Mansur Amirovich Kutlubaev, Allan G. Kermode, Todd Hardy

Research output: Contribution to journalReview articlepeer-review

38 Citations (Web of Science)


Posterior reversible encephalopathy syndrome (PRES) may present with diverse clinical symptoms including visual disturbance, headache, seizures and impaired consciousness. MRI shows oedema, usually involving the posterior subcortical regions. Triggering factors include hypertension, pre-eclampsia/eclampsia, renal failure, cytotoxic agents and autoimmune conditions. The mechanism underlying PRES is not certain, but endothelial dysfunction is implicated. Treatment is supportive and involves correcting the underlying cause and managing associated complications, such as seizures. Although most patients recover, PRES is not always reversible and may be associated with considerable morbidity and even mortality.

Original languageEnglish
Article numberpractneurol-2021-003194
Pages (from-to)183-189
Number of pages7
JournalPractical Neurology
Issue number3
Publication statusPublished - 1 Jun 2022


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