This is the first documented case of post-traumatic Scedosporium inflatum endophthalmitis and only the second of S, inflatum endophthalmitis occurring in a non-immuno-compromised individual, to the authors' knowledge. A case is reported of a 57-year-old woman who, while chopping wood, had a wood chip hit her in the right eye. This caused a penetrating corneal injury with uveal prolapse and damage to the crystalline lens. There were also vitreous and supra-choroidal haemorrhages. No detectable intraocular foreign material was retained. The clinical manifestation of infection was delayed, but once established, it was very destructive, The initially indolent endophthalmitis eventually led to loss of ail light perception and panophthalmitis which required enucleation. The responsible strain of S, inflatum was found to be resistant to all antifungal medication in vitro.