Post-chemotherapy T-cell recovery is a marker of improved survival in patients with advanced thoracic malignancies

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    Abstract

    Background: There is increasing interest in combining chemotherapy with immunotherapy. However, the effects of chemotherapy on the human immune system are largely unknown.Methods: Longitudinal changes in peripheral T-cell subsets in 40 patients with malignant mesothelioma (MM) or advanced non-small cell lung cancer (NSCLC) receiving platinum-based chemotherapy were assessed by flow cytometry and evaluated for associations with clinical outcome.Results: Proliferating T cells of all subsets were almost entirely depleted at day 8 following chemotherapy, but rapidly recovered above baseline levels. Regulatory T cells (Treg) were most profoundly depleted at this time point. A greater increase in CD8+ T-cell proliferation following one treatment cycle was associated with improved overall survival in univariate (hazard ratio (HR)=0.40; P
    Original languageEnglish
    Pages (from-to)1107-1115
    JournalBritish Journal of Cancer
    Volume107
    DOIs
    Publication statusPublished - 25 Sep 2012

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