Post-chemotherapy T-cell recovery is a marker of improved survival in patients with advanced thoracic malignancies

Melanie Mccoy; Richard Lake; Robbert Van Der Most; Ian Dick; Anna Nowak

doi:10.1038/bjc.2012.362

Post-chemotherapy T-cell recovery is a marker of improved survival in patients with advanced thoracic malignancies

Melanie Mccoy, Richard Lake, Robbert Van Der Most, Ian Dick, Anna Nowak

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Background: There is increasing interest in combining chemotherapy with immunotherapy. However, the effects of chemotherapy on the human immune system are largely unknown.Methods: Longitudinal changes in peripheral T-cell subsets in 40 patients with malignant mesothelioma (MM) or advanced non-small cell lung cancer (NSCLC) receiving platinum-based chemotherapy were assessed by flow cytometry and evaluated for associations with clinical outcome.Results: Proliferating T cells of all subsets were almost entirely depleted at day 8 following chemotherapy, but rapidly recovered above baseline levels. Regulatory T cells (Treg) were most profoundly depleted at this time point. A greater increase in CD8+ T-cell proliferation following one treatment cycle was associated with improved overall survival in univariate (hazard ratio (HR)=0.40; P

Original language	English
Pages (from-to)	1107-1115
Journal	British Journal of Cancer
Volume	107
DOIs	https://doi.org/10.1038/bjc.2012.362
Publication status	Published - 25 Sept 2012

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10.1038/bjc.2012.362

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title = "Post-chemotherapy T-cell recovery is a marker of improved survival in patients with advanced thoracic malignancies",

abstract = "Background: There is increasing interest in combining chemotherapy with immunotherapy. However, the effects of chemotherapy on the human immune system are largely unknown.Methods: Longitudinal changes in peripheral T-cell subsets in 40 patients with malignant mesothelioma (MM) or advanced non-small cell lung cancer (NSCLC) receiving platinum-based chemotherapy were assessed by flow cytometry and evaluated for associations with clinical outcome.Results: Proliferating T cells of all subsets were almost entirely depleted at day 8 following chemotherapy, but rapidly recovered above baseline levels. Regulatory T cells (Treg) were most profoundly depleted at this time point. A greater increase in CD8+ T-cell proliferation following one treatment cycle was associated with improved overall survival in univariate (hazard ratio (HR)=0.40; P",

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doi = "10.1038/bjc.2012.362",

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AU - Mccoy, Melanie

AU - Lake, Richard

AU - Van Der Most, Robbert

AU - Dick, Ian

AU - Nowak, Anna

PY - 2012/9/25

Y1 - 2012/9/25

N2 - Background: There is increasing interest in combining chemotherapy with immunotherapy. However, the effects of chemotherapy on the human immune system are largely unknown.Methods: Longitudinal changes in peripheral T-cell subsets in 40 patients with malignant mesothelioma (MM) or advanced non-small cell lung cancer (NSCLC) receiving platinum-based chemotherapy were assessed by flow cytometry and evaluated for associations with clinical outcome.Results: Proliferating T cells of all subsets were almost entirely depleted at day 8 following chemotherapy, but rapidly recovered above baseline levels. Regulatory T cells (Treg) were most profoundly depleted at this time point. A greater increase in CD8+ T-cell proliferation following one treatment cycle was associated with improved overall survival in univariate (hazard ratio (HR)=0.40; P

AB - Background: There is increasing interest in combining chemotherapy with immunotherapy. However, the effects of chemotherapy on the human immune system are largely unknown.Methods: Longitudinal changes in peripheral T-cell subsets in 40 patients with malignant mesothelioma (MM) or advanced non-small cell lung cancer (NSCLC) receiving platinum-based chemotherapy were assessed by flow cytometry and evaluated for associations with clinical outcome.Results: Proliferating T cells of all subsets were almost entirely depleted at day 8 following chemotherapy, but rapidly recovered above baseline levels. Regulatory T cells (Treg) were most profoundly depleted at this time point. A greater increase in CD8+ T-cell proliferation following one treatment cycle was associated with improved overall survival in univariate (hazard ratio (HR)=0.40; P

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EP - 1115

JO - British Journal of Cancer

JF - British Journal of Cancer

ER -

Post-chemotherapy T-cell recovery is a marker of improved survival in patients with advanced thoracic malignancies

Abstract

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