TY - JOUR
T1 - Possible use of Punica granatum (Pomegranate) in cancer therapy
AU - Khwairakpam, Amrita Devi
AU - Bordoloi, Devivasha
AU - Thakur, Krishan Kumar
AU - Monisha, Javadi
AU - Arfuso, Frank
AU - Sethi, Gautam
AU - Mishra, Srishti
AU - Kumar, Alan P.
AU - Kunnumakkara, Ajaikumar B.
N1 - Funding Information:
This work was supported by BT/529/NE/TBP/2013 awarded to Ajaikumar B Kunnumakkara by Department of Biotechnology (DBT), Government of India.
Funding Information:
This work was supported by BT/P/ABK/03, awarded to Dr. Ajaikumar B. Kunnumakkara, by Department of Biotechnology, Government of India.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/7
Y1 - 2018/7
N2 - The intake of fruits has proven to reduce the risk and incidence of cancer worldwide and plays a crucial role in cancer prevention. Pomegranate (Punica granatum), which belongs to the Punicaceae family, is one such plant that contains beneficial nutrients as well as many bioactive components and important phytochemicals that can be attributed to cancer-related therapeutic purposes. Pomegranate possesses antioxidant, anti-inflammatory, anti-proliferative, anti-angiogenic, anti-invasive, and anti-metastatic properties, and induces apoptosis. It also down-regulates various signaling pathways such as NF-κB, PI3K/AKT/mTOR, and Wnt, and down-regulates the expression of genes that are responsible in cancer development, such as anti-apoptotic genes, MMPs, VEGF, c-met, cyclins, Cdks, and pro-inflammatory cytokines. Therefore, inclusion of the fruit in one's diet would assist in a healthy life protected from cancer and also act as an effective chemotherapeutic with no toxic side effects.
AB - The intake of fruits has proven to reduce the risk and incidence of cancer worldwide and plays a crucial role in cancer prevention. Pomegranate (Punica granatum), which belongs to the Punicaceae family, is one such plant that contains beneficial nutrients as well as many bioactive components and important phytochemicals that can be attributed to cancer-related therapeutic purposes. Pomegranate possesses antioxidant, anti-inflammatory, anti-proliferative, anti-angiogenic, anti-invasive, and anti-metastatic properties, and induces apoptosis. It also down-regulates various signaling pathways such as NF-κB, PI3K/AKT/mTOR, and Wnt, and down-regulates the expression of genes that are responsible in cancer development, such as anti-apoptotic genes, MMPs, VEGF, c-met, cyclins, Cdks, and pro-inflammatory cytokines. Therefore, inclusion of the fruit in one's diet would assist in a healthy life protected from cancer and also act as an effective chemotherapeutic with no toxic side effects.
KW - Cancer therapy
KW - Phytochemicals
KW - Pomegranate
KW - Punica granatum
KW - Punicalagin
UR - http://www.scopus.com/inward/record.url?scp=85046650379&partnerID=8YFLogxK
U2 - 10.1016/j.phrs.2018.04.021
DO - 10.1016/j.phrs.2018.04.021
M3 - Review article
C2 - 29729421
AN - SCOPUS:85046650379
SN - 1043-6618
VL - 133
SP - 53
EP - 64
JO - Pharmacological Research
JF - Pharmacological Research
ER -
