Possible relation between structure and spike shapes of neurones in guinea pig cochlear ganglion

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Abstract

A two-component positive single unit spike could be recorded extracellularly from neurones in the acoustic ganglion of the guinea pig cochlea. Light and electron microscopy showed that the bipolar afferent neurones and their processes were myelinated except at nodes of Ranvier on either side of the cell soma, about 40 μm from the point of emergence of the myelinated processes. This anatomical finding and the properties of the two-component spike suggest that impulse conduction in these cells is achieved by rapid successive activation of the low threshold nodes on either side of the cell soma. The possible advantages of such a conduction system are discussed.

Original languageEnglish
Pages (from-to)487-496
Number of pages10
JournalBrain Research
Volume109
Issue number3
DOIs
Publication statusPublished - 18 Jun 1976
Externally publishedYes

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Brain Res. Cited By :20 Export Date: 1 July 2019 Article CODEN: BRREA C2 - 1276931 Correspondence Address: Robertson, D.; Department of Biology, McGill University, Montreal, Que., Canada Funding details: Canadian Poultry Research Council Funding text 1: I thank G. Manley for advice and support during this work and R. Chase for helpful discussion. Also S. Gibbs and J. Marsden for the use of electron microscope facilities. This work was supported by Grants A6368 and E2582 from the Canadian National Research Council. References: Bishop, Burke, Davis, The interpretation of the extracellular response of single lateral geniculate cells (1962) J. Physiol. (Lond.), 162, pp. 451-472; Dowben, Rose, A metal-filled microelectrode (1953) Science, 118, pp. 22-24; Freygang, An analysis of extracellular potentials from single neurons in the lateral geniculate nucleus of the cat (1958) J. gen. Physiol., 41, pp. 543-563; Freygang, Frank, Extracellular potentials from single spinal motoneurons (1959) J. gen. Physiol., 42, pp. 749-760; Getcheld, Analysis of unitary spikes recorded extracellularly from frog olfactory cells and axons (1973) J. Physiol. (Lond.), 234, pp. 533-545; Huxley, Stampfli, Evidence for saltatory conduction in peripheral myelinated nerve fibres (1949) J. Physiol. (Lond.), 108, pp. 315-339; Ito, Saiga, The mode of impulse conduction through the spinal ganglion (1959) Jap. J. Physiol., 9, pp. 33-42; Kellerhals, Engstro¨m, Ades, Die Morphologie des Ganglion spirale cochleae (1967) Acta oto-laryng. (Stockh.); Kiang, (1965) Discharge Patterns of Fibres in the Cat's Auditory Nerve, , MIT Press, Cambridge, Mass; Preston, Kennedy, Integrative synaptic mechanisms in the caudal ganglion of the crayfish (1960) J. gen. Physiol., 43, pp. 671-681; Robertson, Manley, Manipulation of frequency analysis in the cochlear ganglion of the guinea pig (1974) J. comp. Physiol., 91, pp. 363-375; Rosenbluth, The fine structure of acoustic ganglia in the rat (1962) J. Cell Biol., 12, pp. 329-359; Rosenbluth, Palay, The fine structure of nerve cell bodies and their myelin sheaths in the eighth nerve ganglion of the goldfish (1961) J. biochem. biophys. Cytol., 9, pp. 853-877; Ross, Burkel, Multipolar neurons in the spiral ganglion of the rat (1973) Acta otolaryng. (Stockh.), 76, pp. 381-392; Spoendlin, Innervation densities of the cochlea (1972) Acta oto-laryng. (Stockh.), 73, pp. 235-245; Spurr, A low viscosity embedding medium for electron microscopy (1969) J. Ultrastruct. Res., 26, pp. 3-43; Tasaki, (1953) Nervous Transmission, , Thomas, Springfield, Ill; Thomsen, The ultrastructure of the spiral ganglion in the guinea pig (1966) Acta oto-laryng. (Stockh.)

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