Possible prevention of allergic disease by breastfeeding induced oral tolerance

P. Macchiaverni, A. Rekima, M. K. Tulic, V. Verhasselt

    Research output: Contribution to journalShort survey

    2 Citations (Scopus)

    Abstract

    Neonatal immune system faces considerable challenges as it must cope with antigenic stimulus following gut and skin bacterial colonization, and exposure to numerous new environmental antigens while organs are developing requiring low inflammation to allow harmonious growth. In addition to its impact on child growth and prevention of infectious disease, breast-milk may help to educate the immune system towards acceptance of non "dangerous" antigens. Indeed, epidemiological studies report that breastfeeding protects from immune-mediated diseases such as allergy, celiac disease and Type-1 Diabetes. However, data are controversial and mechanisms unclear. Here we will present and discuss experimental data indicating that breastfeeding-induced protection may rely on immune tolerance induction in the breastfed child upon antigen transfer through maternal milk. The tolerogenic potential of breast milk depends on maternal exposure to common environmental and dietary antigens and the efficiency of antigen transfer across mammary epithelium. Induction of tolerance upon breast-milk mediated antigen transfer will also depend on the presence of immunomodulatory factors in breast-milk and of its impact on neonatal gut and immune system maturation. The better understanding of maternal influence on tolerance induction by antigen transfer through breast milk should allow the development of new strategies for prevention of immune mediated diseases.

    Translated title of the contributionPossible prevention of allergic disease by breastfeeding induced oral tolerance
    Original languageFrench
    Pages (from-to)489-495
    Number of pages7
    JournalRevue Francaise d'Allergologie
    Volume52
    Issue number7
    DOIs
    Publication statusPublished - Nov 2012

    Fingerprint

    Breast Feeding
    Human Milk
    Antigens
    Immune System
    Immune System Diseases
    Mothers
    Maternal Exposure
    Immune Tolerance
    Celiac Disease
    Growth
    Type 1 Diabetes Mellitus
    Communicable Diseases
    Epidemiologic Studies
    Hypersensitivity
    Milk
    Breast
    Epithelium
    Inflammation
    Skin

    Cite this

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    title = "L'allaitement maternel peut-il pr{\'e}venir les maladies allergiques par l'induction de tol{\'e}rance orale?",
    abstract = "Neonatal immune system faces considerable challenges as it must cope with antigenic stimulus following gut and skin bacterial colonization, and exposure to numerous new environmental antigens while organs are developing requiring low inflammation to allow harmonious growth. In addition to its impact on child growth and prevention of infectious disease, breast-milk may help to educate the immune system towards acceptance of non {"}dangerous{"} antigens. Indeed, epidemiological studies report that breastfeeding protects from immune-mediated diseases such as allergy, celiac disease and Type-1 Diabetes. However, data are controversial and mechanisms unclear. Here we will present and discuss experimental data indicating that breastfeeding-induced protection may rely on immune tolerance induction in the breastfed child upon antigen transfer through maternal milk. The tolerogenic potential of breast milk depends on maternal exposure to common environmental and dietary antigens and the efficiency of antigen transfer across mammary epithelium. Induction of tolerance upon breast-milk mediated antigen transfer will also depend on the presence of immunomodulatory factors in breast-milk and of its impact on neonatal gut and immune system maturation. The better understanding of maternal influence on tolerance induction by antigen transfer through breast milk should allow the development of new strategies for prevention of immune mediated diseases.",
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    L'allaitement maternel peut-il prévenir les maladies allergiques par l'induction de tolérance orale? / Macchiaverni, P.; Rekima, A.; Tulic, M. K.; Verhasselt, V.

    In: Revue Francaise d'Allergologie, Vol. 52, No. 7, 11.2012, p. 489-495.

    Research output: Contribution to journalShort survey

    TY - JOUR

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    AU - Macchiaverni, P.

    AU - Rekima, A.

    AU - Tulic, M. K.

    AU - Verhasselt, V.

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    N2 - Neonatal immune system faces considerable challenges as it must cope with antigenic stimulus following gut and skin bacterial colonization, and exposure to numerous new environmental antigens while organs are developing requiring low inflammation to allow harmonious growth. In addition to its impact on child growth and prevention of infectious disease, breast-milk may help to educate the immune system towards acceptance of non "dangerous" antigens. Indeed, epidemiological studies report that breastfeeding protects from immune-mediated diseases such as allergy, celiac disease and Type-1 Diabetes. However, data are controversial and mechanisms unclear. Here we will present and discuss experimental data indicating that breastfeeding-induced protection may rely on immune tolerance induction in the breastfed child upon antigen transfer through maternal milk. The tolerogenic potential of breast milk depends on maternal exposure to common environmental and dietary antigens and the efficiency of antigen transfer across mammary epithelium. Induction of tolerance upon breast-milk mediated antigen transfer will also depend on the presence of immunomodulatory factors in breast-milk and of its impact on neonatal gut and immune system maturation. The better understanding of maternal influence on tolerance induction by antigen transfer through breast milk should allow the development of new strategies for prevention of immune mediated diseases.

    AB - Neonatal immune system faces considerable challenges as it must cope with antigenic stimulus following gut and skin bacterial colonization, and exposure to numerous new environmental antigens while organs are developing requiring low inflammation to allow harmonious growth. In addition to its impact on child growth and prevention of infectious disease, breast-milk may help to educate the immune system towards acceptance of non "dangerous" antigens. Indeed, epidemiological studies report that breastfeeding protects from immune-mediated diseases such as allergy, celiac disease and Type-1 Diabetes. However, data are controversial and mechanisms unclear. Here we will present and discuss experimental data indicating that breastfeeding-induced protection may rely on immune tolerance induction in the breastfed child upon antigen transfer through maternal milk. The tolerogenic potential of breast milk depends on maternal exposure to common environmental and dietary antigens and the efficiency of antigen transfer across mammary epithelium. Induction of tolerance upon breast-milk mediated antigen transfer will also depend on the presence of immunomodulatory factors in breast-milk and of its impact on neonatal gut and immune system maturation. The better understanding of maternal influence on tolerance induction by antigen transfer through breast milk should allow the development of new strategies for prevention of immune mediated diseases.

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    KW - Antigen

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    KW - Immune tolerance

    KW - Neonate

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