This thesis examines porous, biocompatible, and antibacterial poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels for tissue engineering applications. PHEMA hydrogels were synthesized by photochemically and thermally induced phase separation polymerization of aqueous formulations containing 2-hydroxyethyl methacrylate, a crosslinker, an initiator, and metal salts. PHEMA doped with silver and gold nanoparticles (Ag PHEMA and Au PHEMA respectively) were prepared in a one-step process, while PHEMA doped with copper nanoparticles (Cu PHEMA) was prepared in a two-step process. Silver nanoparticles slowly leached from Ag PHEMA and conferred antibacterial activity against Escherichia coliand Staphylococcus aureus bacteria but were not toxic to human corneal epithelial cells.
|Qualification||Doctor of Philosophy|
|Award date||17 May 2021|
|Publication status||Unpublished - 2021|