Porous hydrogels doped with nanoparticles of the coinage metals

Praveen Praveen

doi:10.26182/wchr-qe68

Porous hydrogels doped with nanoparticles of the coinage metals

Praveen

Research output: Thesis › Doctoral Thesis

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Abstract

This thesis examines porous, biocompatible, and antibacterial poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels for tissue engineering applications. PHEMA hydrogels were synthesized by photochemically and thermally induced phase separation polymerization of aqueous formulations containing 2-hydroxyethyl methacrylate, a crosslinker, an initiator, and metal salts. PHEMA doped with silver and gold nanoparticles (Ag PHEMA and Au PHEMA respectively) were prepared in a one-step process, while PHEMA doped with copper nanoparticles (Cu PHEMA) was prepared in a two-step process. Silver nanoparticles slowly leached from Ag PHEMA and conferred antibacterial activity against Escherichia coliand Staphylococcus aureus bacteria but were not toxic to human corneal epithelial cells.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Baker, Murray, Supervisor Dorta, Reto, Supervisor Myers, Matthew, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	17 May 2021
DOIs	https://doi.org/10.26182/wchr-qe68
Publication status	Unpublished - 2021

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10.26182/wchr-qe68

THESIS - DOCTOR OF PHILOSOPHY - PRAVEEN - 2021
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Cite this

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abstract = "This thesis examines porous, biocompatible, and antibacterial poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels for tissue engineering applications. PHEMA hydrogels were synthesized by photochemically and thermally induced phase separation polymerization of aqueous formulations containing 2-hydroxyethyl methacrylate, a crosslinker, an initiator, and metal salts. PHEMA doped with silver and gold nanoparticles (Ag PHEMA and Au PHEMA respectively) were prepared in a one-step process, while PHEMA doped with copper nanoparticles (Cu PHEMA) was prepared in a two-step process. Silver nanoparticles slowly leached from Ag PHEMA and conferred antibacterial activity against Escherichia coliand Staphylococcus aureus bacteria but were not toxic to human corneal epithelial cells.",

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AB - This thesis examines porous, biocompatible, and antibacterial poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels for tissue engineering applications. PHEMA hydrogels were synthesized by photochemically and thermally induced phase separation polymerization of aqueous formulations containing 2-hydroxyethyl methacrylate, a crosslinker, an initiator, and metal salts. PHEMA doped with silver and gold nanoparticles (Ag PHEMA and Au PHEMA respectively) were prepared in a one-step process, while PHEMA doped with copper nanoparticles (Cu PHEMA) was prepared in a two-step process. Silver nanoparticles slowly leached from Ag PHEMA and conferred antibacterial activity against Escherichia coliand Staphylococcus aureus bacteria but were not toxic to human corneal epithelial cells.

KW - Metal nanoparticles

KW - Porous

KW - Antibacterial

KW - Biocompatible

U2 - 10.26182/wchr-qe68

DO - 10.26182/wchr-qe68

M3 - Doctoral Thesis

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Porous hydrogels doped with nanoparticles of the coinage metals

Abstract

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