Porous hydrogels doped with nanoparticles of the coinage metals

Research output: ThesisDoctoral Thesis

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Abstract

This thesis examines porous, biocompatible, and antibacterial poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels for tissue engineering applications. PHEMA hydrogels were synthesized by photochemically and thermally induced phase separation polymerization of aqueous formulations containing 2-hydroxyethyl methacrylate, a crosslinker, an initiator, and metal salts. PHEMA doped with silver and gold nanoparticles (Ag PHEMA and Au PHEMA respectively) were prepared in a one-step process, while PHEMA doped with copper nanoparticles (Cu PHEMA) was prepared in a two-step process. Silver nanoparticles slowly leached from Ag PHEMA and conferred antibacterial activity against Escherichia coliand Staphylococcus aureus bacteria but were not toxic to human corneal epithelial cells.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Baker, Murray, Supervisor
  • Dorta, Reto, Supervisor
  • Myers, Matthew, Supervisor
Thesis sponsors
Award date17 May 2021
DOIs
Publication statusUnpublished - 2021

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