Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy

Deane Maria Dmello; Ibnu Ariyanto; Riwanti Estiasari; Samuel Halstrom; Jessica Gaff; Silvia Lee; Patricia Price

doi:10.1016/j.humimm.2017.03.001

Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy

Deane Maria Dmello, Ibnu Ariyanto, Riwanti Estiasari, Samuel Halstrom, Jessica Gaff, Silvia Lee, Patricia Price

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine influenced by single nucleotide polymorphisms (SNP) located in upstream regulatory regions. Here we address the effects of five SNP (rs1518111, rs3021094, rs3024491, rs1800872 and rs1800871) on CD4 T-cell counts in Indonesian HIV patients assessed before ART and over 12. months on treatment. Heterozygosity at rs1518111 or rs1800872 associated with low CD4 T-cell counts at all time points. Both alleles were carried in two haplotypes. Haplotype 2 11. 2 2 (present in 30% of participants) associated with low CD4 T-cell counts, whereas 2 12. 2 2 (in 6% of participants) did not. Hence untyped SNP(s) tagged by 2 11. 2 2 may depress CD4 T-cell counts. The association with heterozygosity suggests synergy with an allele from a haplotype lacking rs1518111 and/or rs1800872.

Original language	English
Pages (from-to)	387-390
Number of pages	4
Journal	Human Immunology
Volume	78
Issue number	4
DOIs	https://doi.org/10.1016/j.humimm.2017.03.001
Publication status	Published - 1 Apr 2017
Externally published	Yes

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title = "Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy",

abstract = "Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine influenced by single nucleotide polymorphisms (SNP) located in upstream regulatory regions. Here we address the effects of five SNP (rs1518111, rs3021094, rs3024491, rs1800872 and rs1800871) on CD4 T-cell counts in Indonesian HIV patients assessed before ART and over 12. months on treatment. Heterozygosity at rs1518111 or rs1800872 associated with low CD4 T-cell counts at all time points. Both alleles were carried in two haplotypes. Haplotype 2 11. 2 2 (present in 30% of participants) associated with low CD4 T-cell counts, whereas 2 12. 2 2 (in 6% of participants) did not. Hence untyped SNP(s) tagged by 2 11. 2 2 may depress CD4 T-cell counts. The association with heterozygosity suggests synergy with an allele from a haplotype lacking rs1518111 and/or rs1800872.",

keywords = "Antiretroviral therapy, CD4 T-cell counts, HIV, IL-10, Indonesia, Single nucleotide polymorphism",

author = "Dmello, {Deane Maria} and Ibnu Ariyanto and Riwanti Estiasari and Samuel Halstrom and Jessica Gaff and Silvia Lee and Patricia Price",

year = "2017",

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doi = "10.1016/j.humimm.2017.03.001",

language = "English",

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T1 - Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy

AU - Dmello, Deane Maria

AU - Ariyanto, Ibnu

AU - Estiasari, Riwanti

AU - Halstrom, Samuel

AU - Gaff, Jessica

AU - Lee, Silvia

AU - Price, Patricia

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine influenced by single nucleotide polymorphisms (SNP) located in upstream regulatory regions. Here we address the effects of five SNP (rs1518111, rs3021094, rs3024491, rs1800872 and rs1800871) on CD4 T-cell counts in Indonesian HIV patients assessed before ART and over 12. months on treatment. Heterozygosity at rs1518111 or rs1800872 associated with low CD4 T-cell counts at all time points. Both alleles were carried in two haplotypes. Haplotype 2 11. 2 2 (present in 30% of participants) associated with low CD4 T-cell counts, whereas 2 12. 2 2 (in 6% of participants) did not. Hence untyped SNP(s) tagged by 2 11. 2 2 may depress CD4 T-cell counts. The association with heterozygosity suggests synergy with an allele from a haplotype lacking rs1518111 and/or rs1800872.

AB - Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine influenced by single nucleotide polymorphisms (SNP) located in upstream regulatory regions. Here we address the effects of five SNP (rs1518111, rs3021094, rs3024491, rs1800872 and rs1800871) on CD4 T-cell counts in Indonesian HIV patients assessed before ART and over 12. months on treatment. Heterozygosity at rs1518111 or rs1800872 associated with low CD4 T-cell counts at all time points. Both alleles were carried in two haplotypes. Haplotype 2 11. 2 2 (present in 30% of participants) associated with low CD4 T-cell counts, whereas 2 12. 2 2 (in 6% of participants) did not. Hence untyped SNP(s) tagged by 2 11. 2 2 may depress CD4 T-cell counts. The association with heterozygosity suggests synergy with an allele from a haplotype lacking rs1518111 and/or rs1800872.

KW - Antiretroviral therapy

KW - CD4 T-cell counts

KW - HIV

KW - IL-10

KW - Indonesia

KW - Single nucleotide polymorphism

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U2 - 10.1016/j.humimm.2017.03.001

DO - 10.1016/j.humimm.2017.03.001

M3 - Article

C2 - 28263776

AN - SCOPUS:85014616719

SN - 0198-8859

VL - 78

SP - 387

EP - 390

JO - Human Immunology

JF - Human Immunology

IS - 4

ER -

Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy

Abstract

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