Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 508-517 |
| Number of pages | 10 |
| Journal | Journal of NeuroVirology |
| Volume | 22 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2016 |
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Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients. / Goullee, Hayley; Wadley, A.L.; Cherry, C.L.; Allcock, Richard J.N.; Black, M.; Kamerman, P.R.; Price, P.
In: Journal of NeuroVirology, Vol. 22, No. 4, 2016, p. 508-517.Research output: Contribution to journal › Article
TY - JOUR
T1 - Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients
AU - Goullee, Hayley
AU - Wadley, A.L.
AU - Cherry, C.L.
AU - Allcock, Richard J.N.
AU - Black, M.
AU - Kamerman, P.R.
AU - Price, P.
PY - 2016
Y1 - 2016
N2 - © 2016, Journal of NeuroVirology, Inc.HIV-associated sensory neuropathy (HIV-SN) is the most common neurological condition associated with HIV. HIV-SN has characteristics of an inflammatory pathology caused by the virus itself and/or by antiretroviral treatment (ART). Here, we assess the impact of single-nucleotide polymorphisms (SNPs) in a cluster of three genes that affect inflammation and neuronal repair: P2X7R, P2X4R and CAMKK2. HIV-SN status was assessed using the Brief Peripheral Neuropathy Screening tool, with SN defined by bilateral symptoms and signs. Forty-five SNPs in P2X7R, P2X4R and CAMKK2 were genotyped using TaqMan fluorescent probes, in DNA samples from 153 HIV+ black Southern African patients exposed to stavudine. Haplotypes were derived using the fastPHASE algorithm, and SNP genotypes and haplotypes associated with HIV-SN were identified. Optimal logistic regression models included demographics (age and height), with SNPs (model p <0.0001; R2 = 0.19) or haplotypes (model p <0.0001; R2 = 0.18, n = 137 excluding patients carrying CAMKK2 haplotypes perfectly associated with SN). Overall, CAMKK2 exhibited the strongest associations with HIV-SN, with two SNPs and six haplotypes predicting SN status in black Southern Africans. This gene warrants further study.
AB - © 2016, Journal of NeuroVirology, Inc.HIV-associated sensory neuropathy (HIV-SN) is the most common neurological condition associated with HIV. HIV-SN has characteristics of an inflammatory pathology caused by the virus itself and/or by antiretroviral treatment (ART). Here, we assess the impact of single-nucleotide polymorphisms (SNPs) in a cluster of three genes that affect inflammation and neuronal repair: P2X7R, P2X4R and CAMKK2. HIV-SN status was assessed using the Brief Peripheral Neuropathy Screening tool, with SN defined by bilateral symptoms and signs. Forty-five SNPs in P2X7R, P2X4R and CAMKK2 were genotyped using TaqMan fluorescent probes, in DNA samples from 153 HIV+ black Southern African patients exposed to stavudine. Haplotypes were derived using the fastPHASE algorithm, and SNP genotypes and haplotypes associated with HIV-SN were identified. Optimal logistic regression models included demographics (age and height), with SNPs (model p <0.0001; R2 = 0.19) or haplotypes (model p <0.0001; R2 = 0.18, n = 137 excluding patients carrying CAMKK2 haplotypes perfectly associated with SN). Overall, CAMKK2 exhibited the strongest associations with HIV-SN, with two SNPs and six haplotypes predicting SN status in black Southern Africans. This gene warrants further study.
U2 - 10.1007/s13365-015-0421-4
DO - 10.1007/s13365-015-0421-4
M3 - Article
VL - 22
SP - 508
EP - 517
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
SN - 1355-0284
IS - 4
ER -