Polysuccinimide, an inexpensive biodegradable polymer, was chemically modified to form copolymers having potential for use as ocular adhesives. Three types of copolymers were obtained: mussel-mimic adhesives; thermoresponsive adhesives and photo-reactive adhesives. The structures of the copolymers were characterised by spectroscopic methods, gel permeation chromatography, and elemental analysis. The viscoelastic properties of the thermoresponsive polymer were evaluated at human physiological temperatures. The adhesion strength of the other polymers was evaluated against bovine ocular tissue. The photo-reactive adhesives showed very promising adhesive ability. The copolymers were toxic to E. coli and S. aureus bacteria, but non-toxic to human corneal epithelial cells.
|Doctor of Philosophy
|20 Nov 2020
|Unpublished - 2020
- Embargoed from 27/11/2020 to 25/11/2021. Made publicly available on 25/11/2021.