@article{47d128e3503e4292834cbd9a88981f59,
title = "Pneumoproteins and biomarkers of inflammation and coagulation do not predict rapid lung function decline in people living with HIV",
abstract = "Chronic obstructive pulmonary disease (COPD) is among the leading causes of death worldwide and HIV is an independent risk factor for the development of COPD. However, the etiology of this increased risk and means to identify persons with HIV (PWH) at highest risk for COPD have remained elusive. Biomarkers may reveal etiologic pathways and allow better COPD risk stratification. We performed a matched case:control study of PWH in the Strategic Timing of Antiretoviral Treatment (START) pulmonary substudy. Cases had rapid lung function decline (> 40 mL/year FEV1 decline) and controls had stable lung function (+ 20 to − 20 mL/year). The analysis was performed in two distinct groups: (1) those who were virally suppressed for at least 6 months and (2) those with untreated HIV (from the START deferred treatment arm). We used linear mixed effects models to test the relationship between case:control status and blood concentrations of pneumoproteins (surfactant protein-D and club cell secretory protein), and biomarkers of inflammation (IL-6 and hsCRP) and coagulation (d-dimer and fibrinogen); concentrations were measured within ± 6 months of first included spirometry. We included an interaction with treatment group (untreated HIV vs viral suppression) to test if associations varied by treatment group. This analysis included 77 matched case:control pairs in the virally suppressed batch, and 42 matched case:control pairs in the untreated HIV batch (n = 238 total) who were followed for a median of 3 years. Median (IQR) CD4 + count was lowest in the controls with untreated HIV at 674 (580, 838). We found no significant associations between case:control status and pneumoprotein or biomarker concentrations in either virally suppressed or untreated PWH. In this cohort of relatively young, recently diagnosed PWH, concentrations of pneumoproteins and biomarkers of inflammation and coagulation were not associated with subsequent rapid lung function decline. Trial registration: NCT00867048 and NCT01797367.",
author = "{INSIGHT START Pulmonary Substudy Group} and MacDonald, {David M.} and Sarah Samorodnitsky and Wendt, {Chris H.} and Baker, {Jason V.} and Gary Collins and Monica Kruk and Lock, {Eric F.} and Roger Paredes and Selvamuthu Poongulali and Weise, {Danielle O.} and Alan Winston and Robin Wood and Kunisaki, {Ken M.} and B. Aagaard and Jansson, {P. O.} and Pearson, {M. T.} and Babiker, {A. G.} and A. Arenas-Pinto and Atako, {N. B.} and E. Dennis and S. Forcat and F. Hudson and B. Jackson and D. Maas and C. Purvis and C. Russell and S. Emery and C. Carey and M. Clewett and S. Jacoby and F. Gordin and M. Vjecha and A. Sanchez and Loria, {G. R.} and Doldan, {M. L.} and A. Moricz and K. Tillmann and V. M{\"u}ller and G. Touloumi and V. Gioukari and O. Anagnostou and P. Herrero and P. Lopez and A. Avihingsanon and P. Rerksirikul and E. Loiza and V. Mingrone and S. Lupo and F. Marconi and D. Daniel and A. Crinejo and M. French and L. Barba and D. Rowling and E. Warzywoda and M. Bloch and S. Agrawal and D. Dwyer and J. Taylor and {van Petersen}, L. and L. Mertens and {De Wit}, S. and K. Kabamba and M. Wolff and G. Allendes and M. Ristola and O. Debham and H. Jessen and A. Jessen and S. Wiebecke and H. Klinker and G. F{\"a}tkenheuer and C. Lehmann and I. Knaevelsrud and M. Rittweger and A. St{\"o}hr and K. Olah and B. Schaaf and M. Hower and T. Harrer and E. Harrer and A. Skoutelis and V. Papastamopoulos and S. Metallidis and O. Tsachouridou and S. Pujari and A. Chitalikar and N. Kumarasamy and F. Beulah and E. Shahar and E. Kedem and D. Turner and Madero, {J. Sierra} and C. Madrigal and Filali, {M. K.El} and I. Erradey and E. Ekong and N. Eriobu and J. Valencia and M. Le{\'o}n and E. Montalb{\'a}n and J. Alave and R. Salazar and J. Vega and {del Portal}, M. and F. Mendo and E. Bakowska and A. Ignatowska and M. Czarnecki and A. Szymczak and R. Wood and M. Rattley and S. Pillay and R. Mngqibisa and T. Ndaba and P. Madlala and V. Estrada and M. Rodrigo and M. Gutierrez and J. Mu{\~n}oz and D. Dalmau and C. Badia and B. Clotet and Llibre, {J. M.} and K. Ruxrungtham and S. Gatechompol and S. Kiertiburanakul and N. Sanmeema and C. Bowonwatanuwong and U. Ampunpong and W. Prasithsirikul and S. Thongyen and P. Chetchotisakd and S. Anunnatsiri and W. Ratanasuwan and P. Werarak and C. Kityo and H. Mugerwa and P. Munderi and J. Lutaakome and A. Clarke and A. Bexley and S. Das and A. Sahota and C. Emerson and S. McKernan and Johnson, {M. A.} and M. Youle and J. Ross and J. Harding and S. Kegg and T. Moussaoui and F. Chen and S. Lynch and {de Burgh-Thomas}, A. and I. Karunaratne and D. Dockrell and C. Bowman and A. Winston and B. Mora-Peris and Chadwick, {D. R.} and P. Lambert and N. Desai and W. Carter and K. Henry and R. Givot and M. Chow and B. Holloway and S. Weis and I. Vecino and R. Novak and G. Culbert and A. Wilkin and L. Mosley and N. Thielman and J. Granholm and V. Watson and C. Clark and J. Santana and I. Boneta and I. Brar and L. Makohon and R. MacArthur and M. Farrough and M. Frank and S. Parker and E. Tedaldi and M. Santiago and S. Koletar and H. Harber and D. Thomas and I. Bica and B. Adams and {Van Dam}, C. and M. Kolber and K. Moreno and A. Brown and B. Wade",
year = "2023",
month = dec,
doi = "10.1038/s41598-023-29739-x",
language = "English",
volume = "13",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group - Macmillan Publishers",
number = "1",
}
