TY - JOUR
T1 - PLGA-Based Curcumin Delivery System
T2 - An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease
AU - Shahbaz, Sanaz Keshavarz
AU - Koushki, Khadijeh
AU - Sathyapalan, Thozhukat
AU - Majeed, Muhammed
AU - Sahebkar, Amirhossein
PY - 2022/2
Y1 - 2022/2
N2 - Progressive degeneration and dysfunction of the nervous system because of oxidative stress, aggregations of misfolded proteins, and neuroinflammation are the key pathological features of neurodegenerative diseases. Alzheimer's disease is a chronic neurodegenerative disorder driven by uncontrolled extracellular deposition of β-amyloid (Aβ) in the amyloid plaques and intracellular accumulation of hyperphosphorylated tau protein. Curcumin is a hydrophobic polyphenol with noticeable neuroprotective and anti-inflammatory effects that can cross the blood-brain barrier. Therefore, it is widely studied for the alleviation of inflammatory and neurological disorders. However, the clinical application of curcumin is limited due to its low aqueous solubility and bioavailability. Recently, nano-based curcumin delivery systems are developed to overcome these limitations effectively. This review article discusses the effects and potential mechanisms of curcumin-loaded PLGA nanoparticles in Alzheimer’s disease.
AB - Progressive degeneration and dysfunction of the nervous system because of oxidative stress, aggregations of misfolded proteins, and neuroinflammation are the key pathological features of neurodegenerative diseases. Alzheimer's disease is a chronic neurodegenerative disorder driven by uncontrolled extracellular deposition of β-amyloid (Aβ) in the amyloid plaques and intracellular accumulation of hyperphosphorylated tau protein. Curcumin is a hydrophobic polyphenol with noticeable neuroprotective and anti-inflammatory effects that can cross the blood-brain barrier. Therefore, it is widely studied for the alleviation of inflammatory and neurological disorders. However, the clinical application of curcumin is limited due to its low aqueous solubility and bioavailability. Recently, nano-based curcumin delivery systems are developed to overcome these limitations effectively. This review article discusses the effects and potential mechanisms of curcumin-loaded PLGA nanoparticles in Alzheimer’s disease.
KW - Cognition
KW - Curcuminoids
KW - Drug delivery
KW - Inflammation
KW - PLGA
KW - Polymer
UR - http://www.scopus.com/inward/record.url?scp=85125601915&partnerID=8YFLogxK
U2 - 10.2174/1570159X19666210823103020
DO - 10.2174/1570159X19666210823103020
M3 - Review article
C2 - 34429054
AN - SCOPUS:85125601915
VL - 20
SP - 309
EP - 323
JO - Current Neuropharmacology
JF - Current Neuropharmacology
SN - 1875-6190
IS - 2
ER -
