PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease

Sanaz Keshavarz Shahbaz, Khadijeh Koushki, Thozhukat Sathyapalan, Muhammed Majeed, Amirhossein Sahebkar

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Progressive degeneration and dysfunction of the nervous system because of oxidative stress, aggregations of misfolded proteins, and neuroinflammation are the key pathological features of neurodegenerative diseases. Alzheimer's disease is a chronic neurodegenerative disorder driven by uncontrolled extracellular deposition of β-amyloid (Aβ) in the amyloid plaques and intracellular accumulation of hyperphosphorylated tau protein. Curcumin is a hydrophobic polyphenol with noticeable neuroprotective and anti-inflammatory effects that can cross the blood-brain barrier. Therefore, it is widely studied for the alleviation of inflammatory and neurological disorders. However, the clinical application of curcumin is limited due to its low aqueous solubility and bioavailability. Recently, nano-based curcumin delivery systems are developed to overcome these limitations effectively. This review article discusses the effects and potential mechanisms of curcumin-loaded PLGA nanoparticles in Alzheimer’s disease.

Original languageEnglish
Pages (from-to)309-323
Number of pages15
JournalCurrent Neuropharmacology
Volume20
Issue number2
DOIs
Publication statusPublished - Feb 2022

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